HitPredict

Interactor 1: I3L3G9 (I3L3G9)
NudE neurodevelopment protein 1
Gene: NDE1

Interactor 2: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	24722188
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000132 - establishment of mitotic spindle orientation GO:0000776 - kinetochore GO:0005813 - centrosome GO:0007059 - chromosome segregation GO:0008017 - microtubule binding and 1 others more... GO:0051301 - cell division
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 642
+	Hs
		155110 NDEL1_HUMAN (3-265): 1.47e-59: 194: 61.65		NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00
+	Hs
		155141 NDE1_HUMAN (1-265): 7.35e-59: 192: 100.00		NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00
+	Hs
		155149 EP15R_HUMAN (6-243): 3.49e-45: 164: 17.72		NDC80_HUMAN (1-642): 1.46e-79: 266: 100.00
+	Hs
		725002 MYH9_HUMAN (2-221): 4.08e-29: 118: 18.18		UACA_HUMAN (191-641): 1.51e-30: 130: 13.88
+	Hs
		724698 EPS15_HUMAN (2-255): 9.14e-43: 157: 14.34		MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50
+	Hs
		787911 EPS15_HUMAN (2-255): 9.14e-43: 157: 14.34		KT33B_HUMAN (266-567): 4.2e-09: 61.1: 19.17
+	Rn
		222472 MRCKA_RAT (2-187): 8.01e-27: 111: 22.79		MRCKA_RAT (181-627): 1.66e-21: 102: 10.82
+	Hs
		724686 MYH9_HUMAN (2-221): 4.08e-29: 118: 18.18		MYH9_HUMAN (181-636): 8.68e-18: 90.2: 9.50
+	Rn
		222476 MRCKA_RAT (2-187): 8.01e-27: 111: 22.79		MRCKB_RAT (266-642): 2.4e-19: 95.2: 10.61
+	Hs
		724687 MYH9_HUMAN (2-221): 4.08e-29: 118: 18.18		MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84
+	Hs
		725097 MYH11_HUMAN (2-210): 5.86e-29: 118: 18.66		MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84
+	Mm
		93570 MYH9_MOUSE (2-213): 2.28e-28: 116: 17.45		DESP_MOUSE (190-642): 1.18e-15: 83.5: 15.27
+	Hs
		724943 MYH9_HUMAN (2-221): 4.08e-29: 118: 18.18		MY18A_HUMAN (210-628): 6.72e-15: 80.8: 14.45
+	Hs
		725035 MYH9_HUMAN (2-221): 4.08e-29: 118: 18.18		MYO5C_HUMAN (194-519): 6.56e-13: 74.5: 9.71
+	Hs
		725095 MYH10_HUMAN (2-214): 5.38e-26: 109: 19.25		MYH10_HUMAN (171-636): 1.34e-15: 83.3: 12.84
+	Hs
		1137917 MRCKA_HUMAN (14-212): 4.61e-09: 59.1: 19.64		MRCKB_HUMAN (258-642): 1.73e-21: 102: 12.78
+	Hs
		1137871 MRCKA_HUMAN (14-212): 4.61e-09: 59.1: 19.64		MRCKA_HUMAN (140-627): 3.84e-19: 94.5: 11.42