HitPredict

Interactor 1: I6L996 (I6L996)
PTK2 protein
Gene: PTK2

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	25416956, unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 680 Hs			1 543
+	Hs
		433329 FAK1_HUMAN (5-680): 0: 651: 97.93		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		522927 FAK1_HUMAN (5-680): 0: 651: 97.93		SRC_HUMAN (1-543): 0: 601: 74.22
+	Gg
		337665 FAK1_CHICK (5-680): 0: 639: 91.89		SRC_CHICK (1-543): 0: 602: 73.67
+	Mm
		403419 FAK1_MOUSE (5-680): 0: 643: 94.68		SRC_MOUSE (1-543): 0: 598: 73.67
+	Hs
		412143 FAK1_HUMAN (5-680): 0: 651: 97.93		FYN_HUMAN (1-543): 0: 582: 72.16
+	Mm
		710126 FAK1_MOUSE (5-680): 0: 643: 94.68		FYN_MOUSE (1-543): 0: 582: 71.98
+	Hs
		454825 FAK1_HUMAN (5-680): 0: 651: 97.93		FGR_HUMAN (1-542): 0: 562: 67.10
+	Hs
		111146 I6L996_HUMAN (1-680): 0: 658: 100.00		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		442812 FAK1_HUMAN (5-680): 0: 651: 97.93		HCK_HUMAN (1-541): 0: 544: 57.49
+	Hs
		411688 FAK1_HUMAN (5-680): 0: 651: 97.93		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		433716 FAK1_HUMAN (5-680): 0: 651: 97.93		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Rn
		936859 FAK2_RAT (9-671): 1.2e-172: 521: 46.25		SRC_RAT (1-543): 0: 600: 73.67
+	Mm
		403463 FAK2_MOUSE (10-671): 1.29e-171: 518: 46.47		SRC_MOUSE (1-543): 0: 598: 73.67
+	Hs
		522984 FAK2_HUMAN (10-671): 3.37e-168: 510: 46.02		SRC_HUMAN (1-543): 0: 601: 74.22
+	Hs
		412191 FAK2_HUMAN (10-671): 3.37e-168: 510: 46.02		FYN_HUMAN (1-543): 0: 582: 72.16
+	Mm
		763399 Q8C2G0_MOUSE (10-671): 5.95e-160: 487: 44.41		FYN_MOUSE (1-543): 0: 582: 71.98
+	Hs
		411720 FAK2_HUMAN (10-671): 3.37e-168: 510: 46.02		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		433760 FAK2_HUMAN (10-671): 3.37e-168: 510: 46.02		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		411606 MARK3_HUMAN (11-653): 1.34e-128: 399: 16.93		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		433589 MARK3_HUMAN (11-653): 1.34e-128: 399: 16.93		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69