HitPredict

Interactor 1: CUL4A (Q3TCH7)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DCAF8 (Q8N7N5)
DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A)
Gene: DCAF8

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	31391242
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Mm			1 591
+	Hs
		1043043 CUL4A_HUMAN (1-759): 0: 931: 95.13		DCAF8_HUMAN (3-542): 3.5e-128: 390: 94.88
+	Hs
		1043405 CUL4B_HUMAN (10-759): 0: 907: 82.40		DCAF8_HUMAN (3-542): 3.5e-128: 390: 94.88
+	Hs
		473596 CUL4A_HUMAN (1-759): 0: 931: 95.13		DC8L2_HUMAN (1-549): 1.07e-109: 343: 65.65
+	Hs
		473597 CUL4B_HUMAN (10-759): 0: 907: 82.40		DC8L2_HUMAN (1-549): 1.07e-109: 343: 65.65
+	Hs
		1043162 CUL4A_HUMAN (1-759): 0: 931: 95.13		DCAF5_HUMAN (147-536): 1.04e-79: 271: 22.72
+	Hs
		1043114 CUL4A_HUMAN (1-759): 0: 931: 95.13		POC1B_HUMAN (377-586): 3.27e-57: 201: 16.59
+	Mm
		1111813 CUL4A_MOUSE (1-759): 0: 956: 100.00		WDTC1_MOUSE (399-591): 7.46e-46: 173: 29.80
+	Hs
		1043102 CUL4A_HUMAN (1-759): 0: 931: 95.13		WDTC1_HUMAN (399-591): 1.03e-45: 173: 30.30
+	Hs
		1043032 CUL4A_HUMAN (1-759): 0: 931: 95.13		DCAF6_HUMAN (409-570): 2.84e-43: 168: 35.76
+	Hs
		1043085 CUL4A_HUMAN (1-759): 0: 931: 95.13		WDR5B_HUMAN (271-579): 1.84e-46: 168: 13.10
+	Hs
		903208 CUL4A_HUMAN (1-759): 0: 931: 95.13		WDR5_HUMAN (272-579): 1.17e-46: 168: 12.82
+	Hs
		1043396 CUL4B_HUMAN (10-759): 0: 907: 82.40		DCAF6_HUMAN (409-570): 2.84e-43: 168: 35.76
+	Hs
		1043441 CUL4B_HUMAN (10-759): 0: 907: 82.40		WDR5B_HUMAN (271-579): 1.84e-46: 168: 13.10
+	Hs
		903209 CUL4B_HUMAN (10-759): 0: 907: 82.40		WDR5_HUMAN (272-579): 1.17e-46: 168: 12.82
+	Hs
		245601 CUL4B_HUMAN (10-759): 0: 907: 82.40		TBL1X_HUMAN (359-590): 1.37e-41: 160: 11.57
+	Hs
		1043157 CUL4A_HUMAN (1-759): 0: 931: 95.13		SNR40_HUMAN (50-258): 8.33e-25: 108: 15.00
+	Hs
		792982 CUL4A_HUMAN (1-759): 0: 931: 95.13		LIS1_HUMAN (499-591): 8.52e-19: 90.7: 10.64
+	Hs
		1043068 CUL4A_HUMAN (1-759): 0: 931: 95.13		WDR82_HUMAN (363-515): 2.09e-15: 79.4: 17.53
+	Hs
		1016274 CUL4B_HUMAN (10-759): 0: 907: 82.40		TBL3_HUMAN (437-589): 5.38e-18: 89.9: 12.03
+	Hs
		1043419 CUL4B_HUMAN (10-759): 0: 907: 82.40		WDR82_HUMAN (363-515): 2.09e-15: 79.4: 17.53