HitPredict

Interactor 1: CBLB (Q3TTA7)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: UBS3A (Q3V3E1)
Ubiquitin-associated and SH3 domain-containing protein A (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)
Gene: Ubash3a

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0050860 - negative regulation of T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Mm			1 624
+	Hs
		883333 CBLB_HUMAN (1-982): 0: 926: 94.30		UBS3A_HUMAN (1-624): 0: 991: 78.40
+	Mm
		1112064 CBLB_MOUSE (1-982): 0: 947: 100.00		UBS3B_MOUSE (1-618): 0: 905: 45.68
+	Hs
		1027618 CBLB_HUMAN (1-982): 0: 926: 94.30		UBS3B_HUMAN (1-618): 0: 914: 46.00
+	Hs
		610317 CBL_HUMAN (25-976): 0: 710: 47.24		UBS3A_HUMAN (1-624): 0: 991: 78.40
+	Hs
		610459 CBL_HUMAN (25-976): 0: 710: 47.24		UBS3B_HUMAN (1-618): 0: 914: 46.00
+	Mm
		1112053 CBLB_MOUSE (1-982): 0: 947: 100.00		GRB2_MOUSE (140-303): 3.25e-46: 164: 21.69
+	Hs
		924539 CBLB_HUMAN (1-982): 0: 926: 94.30		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Mm
		82735 B9EKI5_MOUSE (1-982): 0: 916: 90.53		GRB2_MOUSE (140-303): 3.25e-46: 164: 21.69
+	Mm
		1112072 CBLB_MOUSE (1-982): 0: 947: 100.00		GRAP_MOUSE (140-301): 7.4e-24: 101: 16.87
+	Mm
		1112057 CBLB_MOUSE (1-982): 0: 947: 100.00		SRBS1_MOUSE (242-300): 6.94e-19: 93.3: 38.98
+	Hs
		1027634 CBLB_HUMAN (1-982): 0: 926: 94.30		CD2AP_HUMAN (170-340): 1.1e-25: 114: 20.57
+	Hs
		235501 CBLB_HUMAN (1-982): 0: 926: 94.30		VINEX_HUMAN (165-301): 1.05e-25: 114: 20.86
+	Hs
		298976 CBLB_HUMAN (1-982): 0: 926: 94.30		SRBS2_HUMAN (195-301): 1.5e-24: 111: 25.86
+	Hs
		1027613 CBLB_HUMAN (1-982): 0: 926: 94.30		SH3R1_HUMAN (199-299): 1.5e-14: 79.5: 23.76
+	Hs
		610338 CBL_HUMAN (25-976): 0: 710: 47.24		GRB2_HUMAN (140-303): 7.91e-46: 163: 21.69
+	Hs
		610437 CBL_HUMAN (25-976): 0: 710: 47.24		Q6ICN0_HUMAN (140-303): 8.54e-45: 160: 21.69
+	Dm
		220607 O46034_DROME (27-450): 0: 729: 68.94		GRAP_DROME (136-300): 8.47e-24: 101: 19.88
+	Hs
		235473 CBL_HUMAN (25-976): 0: 710: 47.24		VINEX_HUMAN (165-301): 1.05e-25: 114: 20.86
+	Hs
		298949 CBL_HUMAN (25-976): 0: 710: 47.24		SRBS2_HUMAN (195-301): 1.5e-24: 111: 25.86
+	Hs
		610501 CBL_HUMAN (25-976): 0: 710: 47.24		SRBS1_HUMAN (189-301): 6.91e-24: 109: 27.97