HitPredict

Interactor 1: CBLB (Q3TTA7)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	27474268, 23452850
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction and 1 others more... GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Mm			1 217
+	Hs
		924539 CBLB_HUMAN (1-982): 0: 926: 94.30		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Mm
		411924 CBLB_MOUSE (1-982): 0: 947: 100.00		LCK_MOUSE (3-202): 5.14e-38: 139: 28.44
+	Hs
		411703 CBLB_HUMAN (1-982): 0: 926: 94.30		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Mm
		782847 CBLB_MOUSE (1-982): 0: 947: 100.00		CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57
+	Hs
		1027603 CBLB_HUMAN (1-982): 0: 926: 94.30		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		557678 CBLB_HUMAN (1-982): 0: 926: 94.30		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337458 CBLB_HUMAN (1-982): 0: 926: 94.30		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		1112081 CBLB_MOUSE (1-982): 0: 947: 100.00		ITSN2_MOUSE (2-61): 1.71e-14: 73.8: 35.00
+	Hs
		69208 CBLB_HUMAN (1-982): 0: 926: 94.30		A9UF07_HUMAN (4-139): 1.72e-21: 94: 35.46
+	Mm
		1112072 CBLB_MOUSE (1-982): 0: 947: 100.00		GRAP_MOUSE (3-57): 4.79e-12: 64.6: 34.55
+	Mm
		292684 CBLB_MOUSE (1-982): 0: 947: 100.00		GRAP2_MOUSE (3-55): 1.77e-10: 61.1: 37.74
+	Hs
		548699 CBLB_HUMAN (1-982): 0: 926: 94.30		VAV_HUMAN (3-60): 1.14e-15: 76.9: 43.10
+	Hs
		1027627 CBLB_HUMAN (1-982): 0: 926: 94.30		ITSN2_HUMAN (2-61): 3.57e-15: 75.7: 36.67
+	Hs
		412170 CBLB_HUMAN (1-982): 0: 926: 94.30		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		1027629 CBLB_HUMAN (1-982): 0: 926: 94.30		VAV3_HUMAN (3-57): 6.2e-13: 69: 38.18
+	Hs
		433339 CBLB_HUMAN (1-982): 0: 926: 94.30		YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37
+	Hs
		1027606 CBLB_HUMAN (1-982): 0: 926: 94.30		ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33
+	Hs
		855791 CBLB_HUMAN (1-982): 0: 926: 94.30		VAV2_HUMAN (3-56): 6.02e-11: 63.1: 38.18
+	Hs
		275194 CBLB_HUMAN (1-982): 0: 926: 94.30		GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62
+	Hs
		522956 CBLB_HUMAN (1-982): 0: 926: 94.30		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03