HitPredict

Interactor 1: SRSF6 (Q3TWW8)
Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)
Gene: SRSF6

Interactor 2: CPSF6 (Q6NVF9)
Cleavage and polyadenylation specificity factor subunit 6
Gene: CPSF6

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	34133714
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016607 - nuclear speck GO:1990904 - ribonucleoprotein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 339 Mm			1 551
+	Hs
		1028937 SRSF6_HUMAN (1-323): 2.93e-58: 193: 97.52		CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62
+	Hs
		992791 SRSF1_HUMAN (3-188): 8.8e-53: 176: 36.65		CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62
+	Hs
		1028560 SRSF9_HUMAN (3-222): 3.64e-48: 163: 34.22		CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62
+	Mm
		1156792 RBM4_MOUSE (1-336): 3.43e-42: 151: 17.00		CPSF6_MOUSE (1-520): 1.22e-73: 246: 100.00
+	Hs
		1084602 RBM4_HUMAN (1-335): 1.1e-40: 147: 17.10		CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62
+	Mm
		857339 TIA1_MOUSE (2-334): 2.73e-33: 128: 15.42		CPSF6_MOUSE (1-520): 1.22e-73: 246: 100.00
+	Hs
		992845 SRSF1_HUMAN (3-188): 8.8e-53: 176: 36.65		CPSF7_HUMAN (1-525): 5.21e-54: 191: 40.45
+	Hs
		993771 SRSF4_HUMAN (1-331): 2.67e-48: 170: 63.14		CPSF7_HUMAN (1-525): 5.21e-54: 191: 40.45
+	Hs
		1084591 RBM4B_HUMAN (3-311): 6.84e-16: 79.6: 14.24		CPSF6_HUMAN (1-520): 2.4e-73: 245: 99.62
+	Hs
		516478 SRSF1_HUMAN (3-188): 8.8e-53: 176: 36.65		PABP1_HUMAN (81-445): 7.6e-16: 82.7: 14.75
+	Hs
		516493 SRSF9_HUMAN (3-222): 3.64e-48: 163: 34.22		PABP1_HUMAN (81-445): 7.6e-16: 82.7: 14.75
+	Hs
		992912 SRSF1_HUMAN (3-188): 8.8e-53: 176: 36.65		DIDO1_HUMAN (159-450): 2.18e-10: 65.7: 20.00
+	Hs
		516674 RBM4_HUMAN (1-335): 1.1e-40: 147: 17.10		PABP1_HUMAN (81-445): 7.6e-16: 82.7: 14.75
+	Hs
		474021 PAB4L_HUMAN (1-261): 7.52e-35: 132: 13.67		PABP4_HUMAN (81-479): 5.43e-15: 80: 12.72
+	Mm
		665745 TIA1_MOUSE (2-334): 2.73e-33: 128: 15.42		PABP1_MOUSE (81-445): 4.53e-16: 83.5: 15.01
+	Zm
		8143 A0A1D6ELH4_MAIZE (3-193): 9.13e-24: 104: 15.27		A0A1D6ELH4_MAIZE (82-470): 4.2e-15: 80.4: 11.19
+	Hs
		516471 TIAR_HUMAN (2-120): 2.76e-14: 74.9: 17.89		PABP1_HUMAN (81-445): 7.6e-16: 82.7: 14.75
+	Hs
		516495 PABP4_HUMAN (101-191): 9.2e-13: 71.1: 21.88		PABP1_HUMAN (81-445): 7.6e-16: 82.7: 14.75
+	Hs
		1308748 RBM4B_HUMAN (3-311): 6.84e-16: 79.6: 14.24		DIDO1_HUMAN (159-450): 2.18e-10: 65.7: 20.00
+	Hs
		963541 TIAR_HUMAN (2-120): 2.76e-14: 74.9: 17.89		LFG1_HUMAN (272-366): 1.96e-09: 61.5: 33.33