HitPredict

Interactor 1: PHAG1 (Q3U1F9)
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane phosphoprotein Cbp)
Gene: Pag1

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	26512138
Identification Methods	affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PAG~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 429 Mm			1 217
+	Hs
		924899 PHAG1_HUMAN (1-429): 0: 705: 78.21		GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54
+	Mm
		639443 PHAG1_MOUSE (1-429): 0: 785: 100.00		LYN_MOUSE (3-202): 3.06e-38: 140: 27.49
+	Mm
		411925 PHAG1_MOUSE (1-429): 0: 785: 100.00		LCK_MOUSE (3-202): 5.14e-38: 139: 28.44
+	Mm
		782848 PHAG1_MOUSE (1-429): 0: 785: 100.00		CSK_MOUSE (2-139): 1.12e-23: 99.4: 35.57
+	Mm
		1112224 PHAG1_MOUSE (1-429): 0: 785: 100.00		NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14
+	Rn
		693647 PHAG1_RAT (1-429): 0: 764: 89.51		CSK_RAT (2-139): 1.15e-23: 99.4: 35.57
+	Mm
		654980 PHAG1_MOUSE (1-429): 0: 785: 100.00		VAV_MOUSE (3-60): 1.12e-15: 76.9: 43.10
+	Mm
		763390 PHAG1_MOUSE (1-429): 0: 785: 100.00		FYN_MOUSE (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		789135 PHAG1_HUMAN (1-429): 0: 705: 78.21		FRK_HUMAN (3-202): 7.94e-39: 141: 28.84
+	Hs
		411873 PHAG1_HUMAN (1-429): 0: 705: 78.21		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Hs
		782829 PHAG1_HUMAN (1-429): 0: 705: 78.21		CSK_HUMAN (2-139): 4.25e-24: 100: 36.24
+	Hs
		337571 PHAG1_HUMAN (1-429): 0: 705: 78.21		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		548756 PHAG1_HUMAN (1-429): 0: 705: 78.21		VAV_HUMAN (3-60): 1.14e-15: 76.9: 43.10
+	Hs
		412375 PHAG1_HUMAN (1-429): 0: 705: 78.21		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		523175 PHAG1_HUMAN (1-429): 0: 705: 78.21		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		434038 PHAG1_HUMAN (1-429): 0: 705: 78.21		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39