HitPredict

Interactor 1: PI3R6 (Q3U6Q4)
Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)
Gene: Pik3r6

Interactor 2: PK3CG (Q9JHG7)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Gene: Pik3cg

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	23824069, 21665146, 15797027
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PI3K_1B_p101~PI3K_C2
Common GO terms	GO:0001525 - angiogenesis GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005942 - phosphatidylinositol 3-kinase complex GO:0005944 - phosphatidylinositol 3-kinase complex, class IB
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 756 Mm			1 1102
+	Hs
		822544 PI3R6_HUMAN (1-756): 0: 1181: 82.39		PK3CG_HUMAN (1-1102): 0: 1330: 94.10
+	Mm
		1131705 PI3R5_MOUSE (37-301): 1.33e-90: 304: 25.46		PK3CG_MOUSE (1-1102): 0: 1376: 100.00
+	Ss
		137794 PI3R5_PIG (37-304): 2.61e-89: 301: 24.54		PK3CG_PIG (1-1102): 0: 1354: 94.19
+	Hs
		822548 PI3R5_HUMAN (37-304): 2.91e-91: 306: 24.54		PK3CG_HUMAN (1-1102): 0: 1330: 94.10