HitPredict

Interactor 1: SNX27 (Q3UHD6)
Sorting nexin-27
Gene: SNX27

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36604605
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0035255 - ionotropic glutamate receptor binding GO:0098978 - glutamatergic synapse GO:1904719 - positive regulation of AMPA glutamate receptor clustering
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 539 Mm			1 724
+	Hs
		942344 FRPD4_HUMAN (2-533): 1.88e-68: 241: 15.21		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Mm
		57065 FRPD4_MOUSE (1-533): 2.2e-67: 238: 15.37		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		1062034 FRPD4_HUMAN (2-533): 1.88e-68: 241: 15.21		DLG3_HUMAN (28-724): 0: 600: 64.92
+	Hs
		1021493 FRPD4_HUMAN (2-533): 1.88e-68: 241: 15.21		DLG1_HUMAN (28-724): 0: 576: 72.79
+	Mm
		1143381 SHAN2_MOUSE (41-145): 3.63e-32: 134: 39.05		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Hs
		942399 SHAN2_HUMAN (41-145): 4.96e-32: 133: 38.10		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Hs
		942404 SHAN1_HUMAN (22-173): 1.25e-29: 126: 28.82		DLG4_HUMAN (1-724): 0: 671: 99.59
+	Mm
		1143348 NEB2_MOUSE (38-313): 3.28e-29: 124: 15.87		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Rn
		677802 GRASP_RAT (7-155): 4.64e-30: 123: 25.48		DLG4_RAT (1-724): 0: 671: 99.45
+	Rn
		677807 SHAN1_RAT (41-180): 8.85e-29: 123: 29.29		DLG4_RAT (1-724): 0: 671: 99.45
+	Mm
		88371 SHAN1_MOUSE (41-180): 9.25e-29: 123: 29.29		DLG4_MOUSE (1-724): 0: 671: 100.00
+	Mm
		936181 NEB2_MOUSE (38-313): 3.28e-29: 124: 15.87		DLG3_MOUSE (20-724): 0: 585: 63.94
+	Mm
		1163969 NEB2_MOUSE (38-313): 3.28e-29: 124: 15.87		DLG1_MOUSE (8-724): 0: 577: 68.93
+	Hs
		1132886 SNX27_HUMAN (1-539): 0: 574: 98.34		MPP7_HUMAN (51-193): 7.87e-16: 83.2: 16.08
+	Hs
		1049949 FRPD4_HUMAN (2-533): 1.88e-68: 241: 15.21		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Hs
		1033831 SNTA1_HUMAN (1-432): 7.36e-43: 161: 16.01		SCRIB_HUMAN (58-243): 7.53e-25: 113: 40.72
+	Dm
		113749 M9NFI9_DROME (38-332): 9.59e-37: 148: 14.38		Q9W3H8_DROME (21-160): 5.66e-17: 87.8: 17.86
+	Rn
		1144072 GRASP_RAT (7-155): 4.64e-30: 123: 25.48		CSKP_RAT (31-271): 2.11e-20: 98.6: 14.80
+	Mm
		1164021 NEB2_MOUSE (38-313): 3.28e-29: 124: 15.87		DLG2_MOUSE (234-473): 4.91e-17: 87.8: 21.95
+	Rn
		1144361 SHAN1_RAT (41-180): 8.85e-29: 123: 29.29		DLG2_RAT (234-580): 2.32e-17: 88.6: 19.55