HitPredict

Interactor 1: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Interactor 2: GRIP1 (Q925T6)
Glutamate receptor-interacting protein 1 (GRIP-1)
Gene: GRIP1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21847098
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0030425 - dendrite GO:0035255 - ionotropic glutamate receptor binding GO:0044877 - protein-containing complex binding GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1186 Mm			1 1127
+	Rn
		957055 AGAP2_RAT (1-1186): 0: 1019: 99.07		GRIP1_RAT (1-1127): 0: 683: 96.36
+	Hs
		1304058 AGAP2_HUMAN (1-1147): 0: 987: 94.10		GRIP1_HUMAN (1-1127): 0: 699: 94.95
+	Mm
		88312 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		D3YUZ8_MOUSE (992-1127): 1.4e-17: 90.4: 21.68
+	Mm
		1112635 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DLG2_MOUSE (992-1127): 7.47e-17: 88.1: 21.68
+	Mm
		1112610 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DLG1_MOUSE (11-143): 2.6e-16: 86.6: 24.09
+	Mm
		1112581 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DLG4_MOUSE (998-1124): 1.09e-15: 84.3: 22.39
+	Mm
		1112570 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		Q52KF7_MOUSE (654-744): 7.79e-15: 81.4: 21.88
+	Mm
		936177 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		DLG3_MOUSE (862-1100): 2.53e-13: 76.6: 12.60
+	Mm
		1112634 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		LNX2_MOUSE (840-1113): 1.58e-12: 73.9: 16.37
+	Mm
		100127 AGAP2_MOUSE (1-1186): 0: 1024: 100.00		F6UDT8_MOUSE (26-136): 2.18e-11: 68.7: 26.13
+	Hs
		1300695 AGAP1_HUMAN (384-1145): 0: 713: 53.70		MAGI1_HUMAN (49-1124): 2.5e-36: 152: 11.03
+	Hs
		1319232 GIT1_HUMAN (932-1139): 4.84e-72: 258: 32.88		GRIP2_HUMAN (3-676): 5.64e-39: 159: 19.09
+	Hs
		1049946 GIT2_HUMAN (932-1139): 1.58e-73: 262: 31.98		SCRIB_HUMAN (672-1087): 1.93e-26: 119: 17.06
+	Hs
		1050094 GIT1_HUMAN (932-1139): 4.84e-72: 258: 32.88		SCRIB_HUMAN (672-1087): 1.93e-26: 119: 17.06
+	Hs
		1021587 ASAP1_HUMAN (746-1166): 2.43e-83: 297: 21.99		DLG1_HUMAN (977-1114): 1.44e-11: 70.9: 19.46
+	Hs
		1264864 ARAP2_HUMAN (513-1107): 7.44e-79: 287: 19.24		LIN7C_HUMAN (149-246): 1.86e-09: 60.5: 35.71
+	Hs
		1020239 GIT1_HUMAN (932-1139): 4.84e-72: 258: 32.88		PTN13_HUMAN (816-1097): 4.57e-16: 86.2: 12.54
+	Mm
		1143335 GIT1_MOUSE (932-1139): 6.25e-72: 258: 32.88		DLG4_MOUSE (998-1124): 1.09e-15: 84.3: 22.39