HitPredict

Interactor 1: J3KNF4 (J3KNF4)
Superoxide dismutase copper chaperone
Gene: CCS

Interactor 2: SODC (P00441)
Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1)
Gene: SOD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HMA~Sod_Cu, Sod_Cu~Sod_Cu
Common GO terms	GO:0005507 - copper ion binding GO:0005737 - cytoplasm GO:0006801 - superoxide metabolic process
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 154
+	Hs
		150285 CCS_HUMAN (1-255): 6.47e-127: 362: 100.00		SODC_HUMAN (1-154): 8.73e-72: 214: 100.00
+	Hs
		150282 CCS_HUMAN (1-255): 6.47e-127: 362: 100.00		CCS_HUMAN (4-151): 2.95e-63: 196: 49.32
+	Dm
		52930 A1Z850_DROME (4-247): 6.36e-91: 270: 46.67		SODC_DROME (1-154): 8.71e-66: 199: 61.04
+	At
		1323902 CCS_ARATH (1-237): 7.8e-91: 272: 39.24		SODC3_ARATH (3-152): 2.23e-61: 188: 54.67
+	Sc
		336684 CCS1_YEAST (1-241): 2.16e-77: 236: 26.48		SODC_YEAST (3-153): 8.94e-64: 194: 55.26
+	Hs
		336287 SODC_HUMAN (66-214): 1.59e-66: 204: 47.71		SODC_HUMAN (1-154): 8.73e-72: 214: 100.00
+	Mm
		437595 SODC_MOUSE (66-214): 5.96e-66: 203: 47.71		SODC_MOUSE (1-154): 3.51e-71: 212: 83.77
+	Sc
		336638 SODC_YEAST (67-214): 3.39e-60: 188: 43.14		SODC_YEAST (3-153): 8.94e-64: 194: 55.26
+	Bs
		191652 YOJM_BACSU (71-223): 1.32e-36: 129: 29.45		YOJM_BACSU (6-148): 5.45e-33: 117: 30.00
+	Se
		478760 SODC1_SALTY (72-213): 7.47e-37: 129: 30.92		SODC1_SALTY (36-150): 1.38e-26: 100: 29.69
+	Vv
		644362 SODL_VACCW (70-214): 8.75e-27: 102: 24.14		SODL_VACCW (5-153): 6.68e-25: 94.3: 30.67