HitPredict

Interactor 1: CDKL5 (Q3UTQ8)
Cyclin-dependent kinase-like 5 (EC 2.7.11.22)
Gene: CDKL5

Interactor 2: NEB2 (Q6R891)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: Ppp1r9b

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36417873
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 938 Mm			1 817
+	Mm
		1113297 CDKL5_MOUSE (1-938): 0: 747: 100.00		DLG2_MOUSE (85-704): 1.1e-42: 169: 13.14
+	Mm
		1113274 CDKL5_MOUSE (1-938): 0: 747: 100.00		ERBIN_MOUSE (40-585): 1.14e-39: 160: 13.73
+	Mm
		936178 CDKL5_MOUSE (1-938): 0: 747: 100.00		DLG3_MOUSE (224-734): 1.59e-39: 159: 16.23
+	Mm
		1113263 CDKL5_MOUSE (1-938): 0: 747: 100.00		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		1113306 CDKL5_MOUSE (1-938): 0: 747: 100.00		AFAD_MOUSE (413-639): 1.17e-27: 122: 27.43
+	Rn
		192513 KCC2D_RAT (3-559): 3.01e-138: 425: 19.75		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Rn
		192509 KCC2B_RAT (3-555): 2.54e-137: 423: 20.46		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Mm
		659460 KCC2B_MOUSE (3-555): 1.32e-137: 424: 20.46		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Mm
		1164026 KCC2G_MOUSE (5-555): 2.16e-137: 423: 20.29		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Rn
		192511 KCC2G_RAT (5-555): 7.53e-136: 418: 20.86		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Hs
		1270552 CDKL2_HUMAN (10-461): 4.17e-131: 405: 36.42		NEB2_HUMAN (1-817): 5.5e-113: 365: 95.84
+	Hs
		625559 CDK2_HUMAN (10-303): 1.85e-150: 447: 37.16		RADIL_HUMAN (176-582): 1.35e-44: 176: 18.05
+	Hs
		625515 CDK2_HUMAN (10-303): 1.85e-150: 447: 37.16		LNX2_HUMAN (73-580): 2.53e-36: 148: 12.26
+	Mm
		659457 KCC2B_MOUSE (3-555): 1.32e-137: 424: 20.46		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		1131547 Q5SVI3_MOUSE (3-555): 3.14e-136: 419: 19.53		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		829606 CDK5_MOUSE (10-303): 3.59e-134: 405: 39.19		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Mm
		659459 KCC2B_MOUSE (3-555): 1.32e-137: 424: 20.46		INADL_MOUSE (475-595): 1.73e-11: 70.4: 21.95
+	Ce
		101938 CDK1_CAEEL (10-299): 1.4e-124: 382: 36.24		G1K0W3_CAEEL (463-768): 9.4e-21: 100: 12.77
+	Hs
		415005 CDK1_HUMAN (10-302): 2.96e-136: 411: 37.84		DLG5_HUMAN (424-594): 7.08e-09: 62: 18.75
+	Ce
		105614 CDK1_CAEEL (10-299): 1.4e-124: 382: 36.24		G5ECZ8_CAEEL (116-587): 3.37e-09: 63.1: 9.88