HitPredict - High confidence protein-protein interactions

Interactor 1: CARL2 (Q3V3V9)
Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)
Gene: Carmil2

Interactor 2: CARL2 (Q3V3V9)
Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)
Gene: Carmil2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27647348
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_6~LRR_6
Common GO terms	GO:0001726 - ruffle GO:0001772 - immunological synapse GO:0005543 - phospholipid binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane and 27 others more... GO:0005911 - cell-cell junction GO:0007163 - establishment or maintenance of cell polarity GO:0008290 - F-actin capping protein complex GO:0010592 - positive regulation of lamellipodium assembly GO:0016477 - cell migration GO:0030027 - lamellipodium GO:0030335 - positive regulation of cell migration GO:0031252 - cell leading edge GO:0032729 - positive regulation of type II interferon production GO:0032743 - positive regulation of interleukin-2 production GO:0034315 - regulation of Arp2/3 complex-mediated actin nucleation GO:0042102 - positive regulation of T cell proliferation GO:0044319 - wound healing, spreading of cells GO:0044354 - macropinosome GO:0044877 - protein-containing complex binding GO:0045111 - intermediate filament cytoskeleton GO:0045184 - establishment of protein localization GO:0045591 - positive regulation of regulatory T cell differentiation GO:0048538 - thymus development GO:0048872 - homeostasis of number of cells GO:0050852 - T cell receptor signaling pathway GO:0051639 - actin filament network formation GO:0061339 - establishment or maintenance of monopolar cell polarity GO:0090091 - positive regulation of extracellular matrix disassembly GO:1900029 - positive regulation of ruffle assembly GO:1902745 - positive regulation of lamellipodium organization GO:2000813 - negative regulation of barbed-end actin filament capping
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	1296
Mm

1	1296

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Last updated: 15 Jul 2024