HitPredict

Interactor 1: TIGIT (Q495A1)
T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
Gene: TIGIT

Interactor 2: NECT2 (Q92692)
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
Gene: NECTIN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	21982860, 27978489, 28515320
Identification Methods	pull down, surface plasmon resonance, molecular sieving, x-ray crystallography, protein array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C2-set_2~V-set, V-set~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 244 Hs			1 538
+	Hs
		1115382 TIGIT_HUMAN (1-244): 0: 527: 100.00		NECT3_HUMAN (30-389): 3.83e-72: 241: 25.00
+	Hs
		1115379 TIGIT_HUMAN (1-244): 0: 527: 100.00		NECT4_HUMAN (33-502): 1.4e-66: 225: 21.76
+	Hs
		545119 TIGIT_HUMAN (1-244): 0: 527: 100.00		PVR_HUMAN (25-441): 3.32e-61: 209: 42.72