HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: DLGP3 (Q6PFD5)
Disks large-associated protein 3 (DAP-3) (PSD-95/SAP90-binding protein 3) (SAP90/PSD-95-associated protein 3) (SAPAP3)
Gene: Dlgap3

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	27507650, 28671696, 36417873, 28469556
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GKAP~PDZ_6
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0043197 - dendritic spine GO:0050804 - modulation of chemical synaptic transmission GO:0097110 - scaffold protein binding and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1730 Mm			1 977
+	Rn
		102520 SHAN3_RAT (1-1730): 0: 618: 98.39		G3V7T8_RAT (1-977): 0: 1232: 99.59
+	Hs
		327247 SHAN3_HUMAN (1-1730): 0: 601: 95.21		DLGP3_HUMAN (1-977): 0: 1232: 94.90
+	Mm
		1116003 SHAN3_MOUSE (1-1730): 0: 626: 100.00		DLGP2_MOUSE (1-977): 0: 1084: 45.30
+	Hs
		327248 SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52		DLGP3_HUMAN (1-977): 0: 1232: 94.90
+	Hs
		145954 SHAN3_HUMAN (1-1730): 0: 601: 95.21		DLGP1_HUMAN (1-977): 0: 1078: 38.55
+	Mm
		1116115 SHAN3_MOUSE (1-1730): 0: 626: 100.00		DLGP1_MOUSE (1-977): 0: 1047: 37.73
+	Hs
		1316300 SHAN3_HUMAN (1-1730): 0: 601: 95.21		DLGP2_HUMAN (1-977): 0: 1067: 45.85
+	Rn
		956996 SHAN3_RAT (1-1730): 0: 618: 98.39		DLGP1_RAT (1-977): 0: 1046: 37.83
+	Mm
		69915 SHAN3_MOUSE (1-1730): 0: 626: 100.00		DLGP4_MOUSE (1-977): 0: 949: 35.66
+	Hs
		145956 SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52		DLGP1_HUMAN (1-977): 0: 1078: 38.55
+	Hs
		1316315 SHAN3_HUMAN (1-1730): 0: 601: 95.21		DLGP4_HUMAN (1-977): 0: 937: 35.66
+	Hs
		1349917 SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52		DLGP2_HUMAN (1-977): 0: 1067: 45.85
+	Mm
		1160650 CSKI1_MOUSE (55-1397): 7.52e-114: 397: 15.53		DLGP1_MOUSE (1-977): 0: 1047: 37.73
+	Hs
		1357785 SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52		DLGP4_HUMAN (1-977): 0: 937: 35.66
+	Mm
		1194593 SHAN2_MOUSE (352-1727): 1.03e-90: 328: 35.55		DLGP1_MOUSE (1-977): 0: 1047: 37.73
+	Rn
		956997 SHAN2_RAT (352-1727): 7.52e-89: 322: 35.92		DLGP1_RAT (1-977): 0: 1046: 37.83
+	Rn
		957003 SHAN1_RAT (367-1725): 1.25e-27: 124: 14.14		DLGP2_RAT (1-977): 0: 1072: 45.39
+	Mm
		88376 SHAN1_MOUSE (367-1725): 5.86e-28: 126: 14.36		DLGP1_MOUSE (1-977): 0: 1047: 37.73
+	Rn
		956998 SHAN1_RAT (367-1725): 1.25e-27: 124: 14.14		DLGP1_RAT (1-977): 0: 1046: 37.83
+	Hs
		145958 SHAN1_HUMAN (491-1637): 5.93e-12: 73.4: 14.37		DLGP1_HUMAN (1-977): 0: 1078: 38.55