HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: KCC2D (Q6PHZ2)
Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17)
Gene: Camk2d

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	27507650, 28671696, 28469556
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005737 - cytoplasm GO:0043005 - neuron projection
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1730 Mm			1 499
+	Mm
		515229 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KCC2A_MOUSE (1-474): 0: 542: 87.58
+	Mm
		1116071 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KCC2G_MOUSE (1-478): 0: 532: 79.58
+	Rn
		506766 CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84		KCC2A_RAT (1-474): 0: 542: 87.58
+	Mm
		439494 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KCC4_MOUSE (12-304): 3.43e-73: 241: 44.75
+	Hs
		1038922 SHAN3_HUMAN (1-1730): 0: 601: 95.21		KCC2B_HUMAN (228-478): 1.5e-64: 223: 50.20
+	Mm
		659451 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KCC2B_MOUSE (321-478): 1.32e-51: 185: 79.75
+	Rn
		1144073 CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84		CSKP_RAT (10-308): 1.2e-88: 292: 47.71
+	Hs
		1083221 ANR52_HUMAN (14-494): 3.38e-78: 284: 16.60		KCC4_HUMAN (10-368): 2e-75: 246: 38.52
+	Hs
		166938 ANR28_HUMAN (224-592): 3.91e-43: 174: 14.60		KCC4_HUMAN (10-368): 2e-75: 246: 38.52
+	Hs
		159247 CSKI1_HUMAN (954-1663): 8.42e-09: 62.8: 13.73		CSKP_HUMAN (10-308): 1.58e-88: 292: 47.71