HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: ABI1 (Q8CBW3)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27507650, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0014069 - postsynaptic density GO:0017124 - SH3 domain binding GO:0043005 - neuron projection GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1730 Mm			1 481
+	Rn
		1337546 SHAN3_RAT (1-1730): 0: 618: 98.39		ABI1_RAT (1-481): 7.79e-114: 345: 98.55
+	Hs
		1224640 SHAN3_HUMAN (1-1730): 0: 601: 95.21		ABI1_HUMAN (1-481): 1.34e-109: 336: 93.11
+	Mm
		913885 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ABI2_MOUSE (1-481): 1.24e-81: 261: 65.78
+	Hs
		1316296 SHAN3_HUMAN (1-1730): 0: 601: 95.21		ABI2_HUMAN (1-481): 2.09e-72: 239: 61.79
+	Mm
		1115977 SHAN3_MOUSE (1-1730): 0: 626: 100.00		AMPH_MOUSE (3-476): 5.67e-41: 157: 12.85
+	Mm
		88456 SHAN3_MOUSE (1-1730): 0: 626: 100.00		D3Z656_MOUSE (38-459): 2e-25: 112: 12.97
+	Hs
		1052307 SHAN3_HUMAN (1-1730): 0: 601: 95.21		SRC8_HUMAN (263-475): 1.97e-33: 134: 21.27
+	Rn
		1337443 SHAN3_RAT (1-1730): 0: 618: 98.39		DBNL_RAT (232-476): 3.46e-27: 115: 18.70
+	Mm
		1116160 SHAN3_MOUSE (1-1730): 0: 626: 100.00		PCLO_MOUSE (102-409): 3.4e-18: 90.5: 14.15
+	Hs
		1316309 SHAN3_HUMAN (1-1730): 0: 601: 95.21		DBNL_HUMAN (282-476): 1.51e-26: 113: 19.29
+	Hs
		1078902 SHAN3_HUMAN (1-1730): 0: 601: 95.21		ITSN1_HUMAN (294-480): 4.54e-11: 67.6: 12.82
+	Rn
		1351589 SHAN2_RAT (352-1727): 7.52e-89: 322: 35.92		ABI1_RAT (1-481): 7.79e-114: 345: 98.55
+	Hs
		1052351 SHAN2_HUMAN (8-1727): 2.64e-135: 466: 40.52		SRC8_HUMAN (263-475): 1.97e-33: 134: 21.27
+	Rn
		193489 CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84		O35823_RAT (72-474): 1.41e-60: 209: 61.89
+	Mm
		103595 ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58		ABI2_MOUSE (1-481): 1.24e-81: 261: 65.78
+	Hs
		862039 DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97		SRC8_HUMAN (263-475): 1.97e-33: 134: 21.27
+	Hs
		1021703 Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21		MYO1E_HUMAN (228-476): 2.61e-31: 130: 20.23
+	Hs
		883497 RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21		MYO1E_HUMAN (228-476): 2.61e-31: 130: 20.23
+	Hs
		1021717 ANR50_HUMAN (197-1044): 5.47e-49: 194: 10.39		MYO1E_HUMAN (228-476): 2.61e-31: 130: 20.23
+	Hs
		1078859 MIB1_HUMAN (187-625): 7.14e-50: 195: 10.66		ITSN1_HUMAN (294-480): 4.54e-11: 67.6: 12.82