HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: MYPT1 (Q9DBR7)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1)
Gene: Ppp1r12a

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	29111324
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Ank_2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1730 Mm			1 1029
+	Mm
		1115906 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ANR28_MOUSE (1-371): 2.5e-67: 247: 18.43
+	Mm
		1116002 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ANS1B_MOUSE (1-842): 3.78e-34: 144: 11.97
+	Mm
		103600 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ANK3_MOUSE (163-319): 1.53e-22: 107: 19.62
+	Hs
		980523 SHAN3_HUMAN (1-1730): 0: 601: 95.21		NOTC2_HUMAN (36-142): 7.44e-14: 78.8: 20.56
+	Hs
		862012 DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97		DAPK1_HUMAN (1-421): 1.17e-68: 253: 16.94
+	Hs
		166969 ANR44_HUMAN (2-537): 4.52e-90: 319: 14.66		ANR28_HUMAN (1-328): 8.17e-68: 248: 19.05
+	Hs
		167014 TNKS2_HUMAN (1-544): 1.02e-87: 315: 15.16		ANR28_HUMAN (1-328): 8.17e-68: 248: 19.05
+	Hs
		166869 TNKS1_HUMAN (12-400): 2.92e-79: 291: 16.63		ANR28_HUMAN (1-328): 8.17e-68: 248: 19.05
+	Hs
		166971 ANR52_HUMAN (14-494): 3.38e-78: 284: 16.60		ANR28_HUMAN (1-328): 8.17e-68: 248: 19.05
+	Hs
		310030 TNKS1_HUMAN (12-400): 2.92e-79: 291: 16.63		TNKS1_HUMAN (1-549): 5.91e-59: 223: 15.29
+	Hs
		166919 ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01		ANR28_HUMAN (1-328): 8.17e-68: 248: 19.05
+	Hs
		1329533 TNKS2_HUMAN (1-544): 1.02e-87: 315: 15.16		TNKS2_HUMAN (1-181): 6.37e-45: 178: 19.92
+	Hs
		1318220 TNKS2_HUMAN (1-544): 1.02e-87: 315: 15.16		PP12C_HUMAN (528-1029): 3.13e-32: 137: 23.23
+	Mm
		970499 ANK1_MOUSE (89-1056): 6.66e-81: 298: 11.50		ANS1B_MOUSE (1-842): 3.78e-34: 144: 11.97
+	Hs
		225160 TNKS2_HUMAN (1-544): 1.02e-87: 315: 15.16		MYPT2_HUMAN (1-894): 1.52e-22: 106: 10.20
+	Mm
		103591 ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58		ANK3_MOUSE (163-319): 1.53e-22: 107: 19.62
+	Hs
		980449 ANR44_HUMAN (2-537): 4.52e-90: 319: 14.66		NOTC2_HUMAN (36-142): 7.44e-14: 78.8: 20.56
+	Hs
		225117 TNKS1_HUMAN (12-400): 2.92e-79: 291: 16.63		MYPT2_HUMAN (1-894): 1.52e-22: 106: 10.20
+	Hs
		1021462 Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21		ANK3_HUMAN (1-125): 3.45e-27: 122: 20.64
+	Hs
		225136 ANK3_HUMAN (12-592): 2.9e-68: 258: 15.01		MYPT2_HUMAN (1-894): 1.52e-22: 106: 10.20