HitPredict

Interactor 1: AMOT (Q4VCS5)
Angiomotin
Gene: AMOT

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	25633977, 24981860, 34284061, 19615732
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down, unspecified method, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1084 Hs			1 975
+	Hs
		1222263 AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98		NED4L_HUMAN (1-975): 0: 1033: 100.00
+	Hs
		1119052 AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		1119026 AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808151 AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125503 AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		1222267 AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		1327936 AMOL2_HUMAN (296-902): 3.42e-27: 121: 39.81		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		808183 AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125569 AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125260 SMCA4_HUMAN (46-592): 7.62e-32: 137: 12.59		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		1327928 RRBP1_HUMAN (179-773): 3.57e-12: 73: 12.40		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		808328 AMOL2_HUMAN (296-902): 3.42e-27: 121: 39.81		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125805 AMOL2_HUMAN (296-902): 3.42e-27: 121: 39.81		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		125768 RRBP1_HUMAN (179-773): 3.57e-12: 73: 12.40		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		724896 MYH9_HUMAN (51-655): 1.51e-14: 81.1: 9.31		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		1119083 AMOT_HUMAN (1-1084): 2.27e-101: 346: 100.00		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84
+	Hs
		1222275 AMOL1_HUMAN (1-912): 6.22e-40: 162: 42.98		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84
+	Hs
		1350508 AMOL2_HUMAN (296-902): 3.42e-27: 121: 39.81		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84
+	Hs
		149380 CTRO_HUMAN (533-815): 3.66e-12: 73.4: 12.37		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84
+	Hs
		1170093 SRCAP_HUMAN (828-1033): 1.6e-09: 64.6: 21.40		HECW2_HUMAN (200-564): 1.39e-10: 67.7: 12.84