HitPredict

Interactor 1: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Interactor 2: Q7KZS0 (Q7KZS0)
SUMO-conjugating enzyme UBC9 (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I)
Gene: UBE2I

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	25416956, unassigned1304
Identification Methods	validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 184
+	Hs
		930247 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Dm
		1181452 KLHDB_DROME (3-566): 3.83e-171: 500: 42.23		Q7KNM2_DROME (1-158): 9.6e-65: 197: 75.95
+	Hs
		849329 KEAP1_HUMAN (8-564): 2.73e-161: 475: 35.88		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		307160 KLHL2_HUMAN (13-567): 3.8e-158: 466: 41.36		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		307190 KLHL2_HUMAN (13-567): 3.8e-158: 466: 41.36		Q7KZS0_HUMAN (1-184): 1.19e-72: 218: 100.00
+	Hs
		828997 KEAP1_HUMAN (8-564): 2.73e-161: 475: 35.88		UBE2A_HUMAN (1-157): 1.19e-68: 207: 36.31
+	Hs
		307165 KLHL2_HUMAN (13-567): 3.8e-158: 466: 41.36		UBC9_HUMAN (1-158): 1.17e-69: 210: 86.71
+	Hs
		827935 KEAP1_HUMAN (8-564): 2.73e-161: 475: 35.88		UB2R1_HUMAN (37-137): 5.12e-22: 90.9: 42.86
+	Hs
		849471 KLH13_HUMAN (380-568): 2.64e-43: 165: 28.06		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		849470 KLHL9_HUMAN (380-568): 3.91e-43: 164: 27.55		UB2D1_HUMAN (4-157): 3.15e-74: 221: 31.17
+	Hs
		895941 KLHL3_HUMAN (422-568): 1.81e-34: 139: 36.05		UB2D3_HUMAN (4-157): 8.42e-73: 217: 31.82