HitPredict

Interactor 1: PDLI3 (Q53GG5)
PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein)
Gene: PDLIM3

Interactor 2: PALLD (Q8WX93)
Palladin (SIH002) (Sarcoma antigen NY-SAR-77)
Gene: PALLD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	23414517
Identification Methods	two hybrid, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001725 - stress fiber GO:0003779 - actin binding GO:0005829 - cytosol GO:0030018 - Z disc GO:0030036 - actin cytoskeleton organization and 1 others more... GO:0051371 - muscle alpha-actinin binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 364 Hs			1 1383
+	Hs
		1263188 PDLI7_HUMAN (71-346): 2.3e-17: 84.9: 8.60		PALLD_HUMAN (1-1383): 0: 728: 100.00
+	Hs
		1120855 PDLI3_HUMAN (1-364): 7.33e-67: 217: 100.00		MYPN_HUMAN (2-1383): 1.14e-145: 479: 38.35
+	Hs
		1076453 TRIP6_HUMAN (19-363): 1.59e-28: 117: 13.48		MYPN_HUMAN (2-1383): 1.14e-145: 479: 38.35
+	Hs
		1120862 PDLI3_HUMAN (1-364): 7.33e-67: 217: 100.00		MYOTI_HUMAN (184-654): 1.59e-18: 92.8: 16.63
+	Hs
		256085 PDLI7_HUMAN (71-346): 2.3e-17: 84.9: 8.60		OBSL1_HUMAN (1126-1379): 1.26e-40: 167: 20.00
+	Hs
		608087 PDLI2_HUMAN (1-350): 3.41e-43: 155: 27.12		FGFR4_HUMAN (252-439): 9.56e-17: 88.2: 20.76
+	Hs
		607981 TRIP6_HUMAN (19-363): 1.59e-28: 117: 13.48		FGFR4_HUMAN (252-439): 9.56e-17: 88.2: 20.76
+	Mm
		57002 A2AKD7_MOUSE (4-271): 3.78e-32: 127: 14.23		OBSCN_MOUSE (1012-1132): 9.77e-10: 65.7: 22.31
+	Hs
		234566 PDLI5_HUMAN (222-346): 1.74e-16: 82.5: 15.75		DSCAM_HUMAN (1136-1380): 1.31e-19: 98.1: 15.77
+	Ce
		107557 G5EFG1_CAEEL (91-345): 1.73e-12: 70.7: 15.50		UNC89_CAEEL (976-1249): 7.26e-10: 66.1: 16.49