HitPredict

Interactor 1: PAN3 (Q58A45)
PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3)
Gene: PAN3

Interactor 2: TNR6A (Q8NDV7)
Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)
Gene: TNRC6A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	21981923, 29395067
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 887 Hs			1 1962
+	Hs
		1123139 PAN3_HUMAN (45-887): 0: 738: 100.00		TNR6B_HUMAN (44-1944): 3.32e-153: 521: 33.57
+	Hs
		1123134 PAN3_HUMAN (45-887): 0: 738: 100.00		TNR6C_HUMAN (35-1957): 8.26e-150: 513: 37.01
+	Dm
		1249008 PAN3_DROME (303-883): 6.43e-120: 384: 43.96		GAWKY_DROME (718-1889): 1.06e-50: 200: 20.88
+	Dm
		87998 D3DMN9_DROME (303-883): 6.35e-120: 384: 43.96		GAWKY_DROME (718-1889): 1.06e-50: 200: 20.88
+	Hs
		555722 NEK4_HUMAN (488-766): 2e-32: 137: 16.17		PGCA_HUMAN (63-1695): 7.59e-16: 86.5: 10.74
+	Hs
		229976 NUAK1_HUMAN (464-748): 5.64e-25: 112: 14.98		TARA_HUMAN (38-1689): 5.35e-20: 100: 8.89
+	Hs
		625532 CDK2_HUMAN (491-716): 1.04e-24: 107: 14.52		CBP_HUMAN (735-1745): 8.61e-21: 102: 9.54
+	Hs
		625393 CDK2_HUMAN (491-716): 1.04e-24: 107: 14.52		EP300_HUMAN (789-1765): 6.73e-09: 63.6: 9.05