HitPredict

Interactor 1: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Interactor 2: MYLK4 (Q86YV6)
Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)
Gene: MYLK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	28514442, 33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 388
+	Hs
		438328 HS90B_HUMAN (1-504): 0: 671: 69.93		MYLK4_HUMAN (1-388): 3.73e-139: 403: 100.00
+	Hs
		437928 HS90B_HUMAN (1-504): 0: 671: 69.93		AKT2_HUMAN (10-380): 4.47e-137: 401: 22.86
+	Mm
		513660 HS90B_MOUSE (1-504): 0: 673: 70.11		AKT1_MOUSE (3-386): 4.91e-135: 396: 23.68
+	Hs
		438633 HS90B_HUMAN (1-504): 0: 671: 69.93		AKT3_HUMAN (7-386): 4.81e-135: 396: 23.02
+	Bt
		964601 HS90B_BOVIN (1-504): 0: 670: 69.76		AKT1_BOVIN (6-386): 1.66e-135: 397: 23.86
+	Hs
		437927 HS90B_HUMAN (1-504): 0: 671: 69.93		AKT1_HUMAN (3-386): 2.96e-134: 394: 23.68
+	Hs
		438224 HS90B_HUMAN (1-504): 0: 671: 69.93		MYLK3_HUMAN (27-378): 3.38e-129: 392: 60.80
+	Hs
		431572 HS90A_HUMAN (1-504): 0: 655: 62.96		AKT1_HUMAN (3-386): 2.96e-134: 394: 23.68
+	Hs
		438441 HS90B_HUMAN (1-504): 0: 671: 69.93		KCC1G_HUMAN (93-384): 4.51e-127: 376: 33.56
+	Hs
		438519 HS90B_HUMAN (1-504): 0: 671: 69.93		MYLK2_HUMAN (30-388): 3.9e-124: 372: 50.69
+	Hs
		437900 HS90B_HUMAN (1-504): 0: 671: 69.93		KAPCB_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		438148 HS90B_HUMAN (1-504): 0: 671: 69.93		KCC2D_HUMAN (104-370): 3.52e-124: 369: 35.06
+	Hs
		431538 HS90A_HUMAN (1-504): 0: 655: 62.96		KAPCB_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		70435 HS90A_HUMAN (1-504): 0: 655: 62.96		B2RB89_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		200083 HS90B_HUMAN (1-504): 0: 671: 69.93		DAPK3_HUMAN (94-361): 2.46e-71: 232: 43.48
+	Hs
		200082 HS90A_HUMAN (1-504): 0: 655: 62.96		DAPK3_HUMAN (94-361): 2.46e-71: 232: 43.48
+	Hs
		437842 HS90B_HUMAN (1-504): 0: 671: 69.93		KPSH1_HUMAN (84-361): 1e-54: 187: 38.25
+	Hs
		438447 HS90B_HUMAN (1-504): 0: 671: 69.93		PSKH2_HUMAN (111-361): 3.66e-53: 182: 38.19
+	Hs
		438631 HS90B_HUMAN (1-504): 0: 671: 69.93		KCC2A_HUMAN (110-362): 3.53e-50: 177: 37.35
+	Hs
		431475 HS90A_HUMAN (1-504): 0: 655: 62.96		KPSH1_HUMAN (84-361): 1e-54: 187: 38.25