HitPredict

Interactor 1: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Interactor 2: CDK20 (Q8IZL9)
Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)
Gene: CDK20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32707033
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 346
+	Hs
		437908 HS90B_HUMAN (1-504): 0: 671: 69.93		CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10
+	Hs
		438075 HS90B_HUMAN (1-504): 0: 671: 69.93		CDK3_HUMAN (1-308): 3.83e-138: 395: 44.66
+	Hs
		438342 HS90B_HUMAN (1-504): 0: 671: 69.93		CDK20_HUMAN (1-346): 2.32e-134: 387: 100.00
+	Hs
		431549 HS90A_HUMAN (1-504): 0: 655: 62.96		CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10
+	Hs
		431741 HS90A_HUMAN (1-504): 0: 655: 62.96		CDK3_HUMAN (1-308): 3.83e-138: 395: 44.66
+	Hs
		432045 HS90A_HUMAN (1-504): 0: 655: 62.96		CDK20_HUMAN (1-346): 2.32e-134: 387: 100.00
+	Hs
		438004 HS90B_HUMAN (1-504): 0: 671: 69.93		CDK7_HUMAN (3-304): 2.01e-127: 370: 42.62
+	Hs
		438077 HS90B_HUMAN (1-504): 0: 671: 69.93		CDK5_HUMAN (1-294): 2.23e-128: 370: 45.09
+	Hs
		960099 H90B4_HUMAN (1-505): 0: 644: 100.00		CDK3_HUMAN (1-308): 3.83e-138: 395: 44.66
+	Hs
		414683 HS90A_HUMAN (1-504): 0: 655: 62.96		CDK1_HUMAN (1-292): 1.16e-131: 379: 42.18
+	Hs
		431662 HS90A_HUMAN (1-504): 0: 655: 62.96		CDK7_HUMAN (3-304): 2.01e-127: 370: 42.62
+	Hs
		431743 HS90A_HUMAN (1-504): 0: 655: 62.96		CDK5_HUMAN (1-294): 2.23e-128: 370: 45.09
+	Hs
		841223 H90B4_HUMAN (1-505): 0: 644: 100.00		CDK7_HUMAN (3-304): 2.01e-127: 370: 42.62
+	Hs
		538107 ENPL_HUMAN (1-504): 0: 597: 35.70		CDK2_HUMAN (1-296): 5.66e-140: 400: 43.10
+	Sp
		383458 HSP90_SCHPO (1-504): 0: 598: 48.51		CDK1_SCHPO (1-292): 4.02e-132: 380: 42.48
+	Ca
		793050 HSP90_CANAL (1-504): 0: 586: 44.48		CDK1_CANAL (1-288): 1.37e-131: 379: 43.15
+	Sc
		339312 HSP82_YEAST (1-504): 0: 585: 45.53		CDK1_YEAST (3-291): 1.14e-124: 361: 42.71
+	Sc
		339406 HSC82_YEAST (1-504): 0: 582: 44.66		CDK1_YEAST (3-291): 1.14e-124: 361: 42.71
+	Hs
		841224 H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87		CDK7_HUMAN (3-304): 2.01e-127: 370: 42.62