HitPredict

Interactor 1: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Interactor 2: MK15 (Q8TD08)
Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)
Gene: MAPK15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32707033
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 544
+	Hs
		438381 HS90B_HUMAN (1-504): 0: 671: 69.93		MK15_HUMAN (1-544): 0: 545: 100.00
+	Hs
		432091 HS90A_HUMAN (1-504): 0: 655: 62.96		MK15_HUMAN (1-544): 0: 545: 100.00
+	Hs
		538326 ENPL_HUMAN (1-504): 0: 597: 35.70		MK15_HUMAN (1-544): 0: 545: 100.00
+	Hs
		437908 HS90B_HUMAN (1-504): 0: 671: 69.93		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		438208 HS90B_HUMAN (1-504): 0: 671: 69.93		MK14_HUMAN (8-355): 1.49e-135: 399: 38.92
+	Hs
		438075 HS90B_HUMAN (1-504): 0: 671: 69.93		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Hs
		431549 HS90A_HUMAN (1-504): 0: 655: 62.96		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		431896 HS90A_HUMAN (1-504): 0: 655: 62.96		MK14_HUMAN (8-355): 1.49e-135: 399: 38.92
+	Hs
		431741 HS90A_HUMAN (1-504): 0: 655: 62.96		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Mm
		432419 HS90A_MOUSE (1-504): 0: 652: 61.81		MK01_MOUSE (1-352): 3.16e-136: 400: 39.44
+	Hs
		960099 H90B4_HUMAN (1-505): 0: 644: 100.00		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Hs
		538107 ENPL_HUMAN (1-504): 0: 597: 35.70		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Sc
		365698 HSP82_YEAST (1-504): 0: 585: 45.53		KSS1_YEAST (1-346): 4.36e-138: 405: 41.14
+	Rn
		600340 HS90B_RAT (1-504): 0: 673: 70.11		MK03_RAT (12-313): 1.32e-77: 251: 45.25
+	Hs
		437913 HS90B_HUMAN (1-504): 0: 671: 69.93		MK03_HUMAN (12-313): 8.66e-78: 251: 45.25
+	Hs
		431555 HS90A_HUMAN (1-504): 0: 655: 62.96		MK03_HUMAN (12-313): 8.66e-78: 251: 45.25
+	Rn
		600383 HS90A_RAT (1-504): 0: 654: 61.98		MK03_RAT (12-313): 1.32e-77: 251: 45.25
+	Mm
		432433 HS90A_MOUSE (1-504): 0: 652: 61.81		MK03_MOUSE (12-313): 1.32e-77: 251: 45.25
+	At
		850798 HS903_ARATH (1-504): 0: 630: 49.56		MPK10_ARATH (17-313): 7.11e-80: 257: 45.33
+	Rn
		600453 ENPL_RAT (1-504): 0: 604: 35.70		MK03_RAT (12-313): 1.32e-77: 251: 45.25