HitPredict

Interactor 1: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Interactor 2: TSSK2 (Q96PF2)
Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B)
Gene: TSSK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32707033
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 358
+	Hs
		438490 HS90B_HUMAN (1-504): 0: 671: 69.93		TSSK1_HUMAN (1-336): 8.66e-147: 420: 67.61
+	Hs
		432226 HS90A_HUMAN (1-504): 0: 655: 62.96		TSSK1_HUMAN (1-336): 8.66e-147: 420: 67.61
+	Hs
		438442 HS90B_HUMAN (1-504): 0: 671: 69.93		TSSK2_HUMAN (1-358): 2.62e-135: 391: 100.00
+	Hs
		437928 HS90B_HUMAN (1-504): 0: 671: 69.93		AKT2_HUMAN (4-341): 6.4e-132: 387: 25.07
+	Mm
		513660 HS90B_MOUSE (1-504): 0: 673: 70.11		AKT1_MOUSE (4-341): 4.16e-131: 385: 25.87
+	Bt
		964601 HS90B_BOVIN (1-504): 0: 670: 69.76		AKT1_BOVIN (4-344): 6.99e-132: 387: 25.65
+	Hs
		438633 HS90B_HUMAN (1-504): 0: 671: 69.93		AKT3_HUMAN (4-341): 4.35e-131: 385: 26.09
+	Hs
		432168 HS90A_HUMAN (1-504): 0: 655: 62.96		TSSK2_HUMAN (1-358): 2.62e-135: 391: 100.00
+	Hs
		431573 HS90A_HUMAN (1-504): 0: 655: 62.96		AKT2_HUMAN (4-341): 6.4e-132: 387: 25.07
+	Hs
		432376 HS90A_HUMAN (1-504): 0: 655: 62.96		AKT3_HUMAN (4-341): 4.35e-131: 385: 26.09
+	Rn
		812703 HS90A_RAT (1-504): 0: 654: 61.98		AKT1_RAT (4-341): 3.5e-131: 385: 25.87
+	Mm
		432411 HS90A_MOUSE (1-504): 0: 652: 61.81		AKT1_MOUSE (4-341): 4.16e-131: 385: 25.87
+	Hs
		1123447 H90B4_HUMAN (1-505): 0: 644: 100.00		AKT3_HUMAN (4-341): 4.35e-131: 385: 26.09
+	Hs
		438443 HS90B_HUMAN (1-504): 0: 671: 69.93		TSSK3_HUMAN (7-272): 4.55e-89: 270: 47.74
+	Hs
		432170 HS90A_HUMAN (1-504): 0: 655: 62.96		TSSK3_HUMAN (7-272): 4.55e-89: 270: 47.74
+	Hs
		438489 HS90B_HUMAN (1-504): 0: 671: 69.93		TSSK6_HUMAN (1-273): 1.82e-79: 246: 46.35
+	Hs
		432225 HS90A_HUMAN (1-504): 0: 655: 62.96		TSSK6_HUMAN (1-273): 1.82e-79: 246: 46.35
+	Hs
		1123436 H90B4_HUMAN (1-505): 0: 644: 100.00		TSSK6_HUMAN (1-273): 1.82e-79: 246: 46.35
+	Hs
		438641 HS90B_HUMAN (1-504): 0: 671: 69.93		SIK3_HUMAN (12-273): 3.37e-51: 185: 37.88
+	Hs
		432384 HS90A_HUMAN (1-504): 0: 655: 62.96		SIK3_HUMAN (12-273): 3.37e-51: 185: 37.88