HitPredict

Interactor 1: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Interactor 2: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 859
+	Mm
		1174807 Q71LX8_MOUSE (1-504): 0: 673: 70.11		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Hs
		438614 HS90B_HUMAN (1-504): 0: 671: 69.93		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Mm
		432448 HS90A_MOUSE (1-504): 0: 652: 61.81		AGO2_MOUSE (1-859): 0: 1219: 99.19
+	Hs
		432355 HS90A_HUMAN (1-504): 0: 655: 62.96		AGO2_HUMAN (1-859): 0: 1205: 100.00
+	Hs
		438615 HS90B_HUMAN (1-504): 0: 671: 69.93		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		432356 HS90A_HUMAN (1-504): 0: 655: 62.96		AGO1_HUMAN (17-859): 0: 1182: 83.16
+	Hs
		438537 HS90B_HUMAN (1-504): 0: 671: 69.93		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		432271 HS90A_HUMAN (1-504): 0: 655: 62.96		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Hs
		438545 HS90B_HUMAN (1-504): 0: 671: 69.93		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		1123440 H90B4_HUMAN (1-505): 0: 644: 100.00		AGO3_HUMAN (5-859): 0: 1165: 79.75
+	Dm
		365460 HSP83_DROME (1-504): 0: 669: 57.69		Q32KD4_DROME (6-859): 0: 1136: 73.10
+	Hs
		432278 HS90A_HUMAN (1-504): 0: 655: 62.96		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		1123442 H90B4_HUMAN (1-505): 0: 644: 100.00		AGO4_HUMAN (16-859): 0: 1145: 78.51
+	Hs
		432159 HS90A_HUMAN (1-504): 0: 655: 62.96		PIWL1_HUMAN (23-826): 0: 751: 22.45
+	Hs
		432088 HS90A_HUMAN (1-504): 0: 655: 62.96		PIWL2_HUMAN (5-821): 0: 735: 21.74
+	Dm
		365485 HSP83_DROME (1-504): 0: 669: 57.69		AGO2_DROME (30-818): 0: 713: 31.09
+	Hs
		432003 HS90A_HUMAN (1-504): 0: 655: 62.96		PIWL4_HUMAN (22-822): 0: 686: 22.07
+	Dm
		365462 HSP83_DROME (1-504): 0: 669: 57.69		AGO3_DROME (31-826): 0: 638: 20.89
+	Dm
		365480 HSP83_DROME (1-504): 0: 669: 57.69		PIWI_DROME (5-826): 0: 628: 21.56
+	Hs
		431946 HS90A_HUMAN (1-504): 0: 655: 62.96		Q5TA56_HUMAN (5-218): 4.02e-88: 280: 62.33