HitPredict

Interactor 1: H90B3 (Q58FF7)
Putative heat shock protein HSP 90-beta-3 (Heat shock protein 90-beta c) (Heat shock protein 90Bc)
Gene: HSP90AB3P

Interactor 2: CDKL4 (Q5MAI5)
Cyclin-dependent kinase-like 4 (EC 2.7.11.22)
Gene: CDKL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 597 Hs			1 379
+	Hs
		960137 H90B3_HUMAN (1-597): 0: 838: 100.00		CDKL1_HUMAN (1-320): 5.83e-132: 383: 66.67
+	Hs
		437908 HS90B_HUMAN (1-597): 0: 799: 75.00		CDK2_HUMAN (1-292): 3.58e-140: 402: 37.76
+	Hs
		431549 HS90A_HUMAN (1-597): 0: 798: 66.67		CDK2_HUMAN (1-292): 3.58e-140: 402: 37.76
+	Hs
		438250 HS90B_HUMAN (1-597): 0: 799: 75.00		CDKL4_HUMAN (1-379): 2.28e-137: 398: 100.00
+	Hs
		431937 HS90A_HUMAN (1-597): 0: 798: 66.67		CDKL4_HUMAN (1-379): 2.28e-137: 398: 100.00
+	Hs
		438075 HS90B_HUMAN (1-597): 0: 799: 75.00		CDK3_HUMAN (1-297): 3.87e-138: 397: 39.47
+	Mm
		513710 HS90B_MOUSE (1-597): 0: 802: 77.35		MK07_MOUSE (2-365): 1.9e-130: 394: 25.33
+	Rn
		92848 HS90B_RAT (1-597): 0: 802: 77.35		E9PTH2_RAT (2-365): 1.88e-130: 394: 25.33
+	Hs
		431741 HS90A_HUMAN (1-597): 0: 798: 66.67		CDK3_HUMAN (1-297): 3.87e-138: 397: 39.47
+	Hs
		438129 HS90B_HUMAN (1-597): 0: 799: 75.00		MK07_HUMAN (2-365): 5.34e-131: 396: 24.80
+	Hs
		431807 HS90A_HUMAN (1-597): 0: 798: 66.67		MK07_HUMAN (2-365): 5.34e-131: 396: 24.80
+	Hs
		414683 HS90A_HUMAN (1-597): 0: 798: 66.67		CDK1_HUMAN (1-291): 4.58e-132: 381: 37.42
+	Hs
		438077 HS90B_HUMAN (1-597): 0: 799: 75.00		CDK5_HUMAN (1-292): 1.51e-130: 377: 37.76
+	Hs
		431743 HS90A_HUMAN (1-597): 0: 798: 66.67		CDK5_HUMAN (1-292): 1.51e-130: 377: 37.76
+	Mm
		513676 HS90B_MOUSE (1-597): 0: 802: 77.35		CDKL5_MOUSE (1-288): 5.7e-86: 281: 46.74
+	Hs
		841224 H90B3_HUMAN (1-597): 0: 838: 100.00		CDK7_HUMAN (2-288): 1.63e-62: 205: 38.87
+	Hs
		438004 HS90B_HUMAN (1-597): 0: 799: 75.00		CDK7_HUMAN (2-288): 1.63e-62: 205: 38.87
+	Hs
		431662 HS90A_HUMAN (1-597): 0: 798: 66.67		CDK7_HUMAN (2-288): 1.63e-62: 205: 38.87
+	Hs
		438342 HS90B_HUMAN (1-597): 0: 799: 75.00		CDK20_HUMAN (1-286): 1.24e-59: 198: 38.41
+	Hs
		432045 HS90A_HUMAN (1-597): 0: 798: 66.67		CDK20_HUMAN (1-286): 1.24e-59: 198: 38.41