HitPredict

Interactor 1: HS905 (Q58FG0)
Putative heat shock protein HSP 90-alpha A5 (Heat shock protein 90-alpha E) (Heat shock protein 90Ae)
Gene: HSP90AA5P

Interactor 2: PDK1L (Q8N165)
Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like)
Gene: PDIK1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	28514442, 33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 334 Hs			1 341
+	Hs
		1123489 HS905_HUMAN (1-334): 1.88e-109: 323: 100.00		STK35_HUMAN (3-332): 1.4e-127: 377: 68.73
+	Hs
		960100 HS905_HUMAN (1-334): 1.88e-109: 323: 100.00		CDK3_HUMAN (5-332): 1.5e-112: 330: 21.22
+	Hs
		1123429 H90B4_HUMAN (22-280): 3.47e-71: 231: 33.53		STK35_HUMAN (3-332): 1.4e-127: 377: 68.73
+	Hs
		1123428 H90B4_HUMAN (22-280): 3.47e-71: 231: 33.53		MK15_HUMAN (2-340): 1.49e-110: 334: 21.91
+	Hs
		960099 H90B4_HUMAN (22-280): 3.47e-71: 231: 33.53		CDK3_HUMAN (5-332): 1.5e-112: 330: 21.22
+	Hs
		1123422 H90B4_HUMAN (22-280): 3.47e-71: 231: 33.53		PDK1L_HUMAN (1-341): 1.05e-110: 327: 100.00
+	Hs
		1123454 H90B3_HUMAN (230-330): 2.48e-21: 96.7: 40.78		STK35_HUMAN (3-332): 1.4e-127: 377: 68.73
+	Hs
		438385 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		STK35_HUMAN (3-332): 1.4e-127: 377: 68.73
+	Hs
		437908 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		CDK2_HUMAN (5-337): 6.66e-114: 334: 21.78
+	Hs
		438381 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		MK15_HUMAN (2-340): 1.49e-110: 334: 21.91
+	Hs
		438075 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		CDK3_HUMAN (5-332): 1.5e-112: 330: 21.22
+	Hs
		438344 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		PDK1L_HUMAN (1-341): 1.05e-110: 327: 100.00
+	Hs
		851527 H90B2_HUMAN (21-280): 5.42e-80: 250: 55.13		NEK4_HUMAN (8-320): 9.2e-19: 89.4: 24.92
+	Hs
		1123413 H90B4_HUMAN (22-280): 3.47e-71: 231: 33.53		ULK3_HUMAN (6-251): 1.66e-19: 90.9: 29.30
+	Mm
		250790 HS90A_MOUSE (22-160): 8.73e-22: 98.2: 73.97		ULK1_MOUSE (112-278): 2.73e-19: 90.9: 33.72
+	Hs
		438277 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		ULK3_HUMAN (6-251): 1.66e-19: 90.9: 29.30
+	Hs
		851526 H90B3_HUMAN (230-330): 2.48e-21: 96.7: 40.78		NEK4_HUMAN (8-320): 9.2e-19: 89.4: 24.92
+	Hs
		438015 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		NEK4_HUMAN (8-320): 9.2e-19: 89.4: 24.92
+	Hs
		262221 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		ULK1_HUMAN (112-278): 1.48e-18: 89: 33.14
+	Hs
		438350 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		DCLK2_HUMAN (7-251): 3.08e-18: 87.8: 30.00