HitPredict

Interactor 1: HS905 (Q58FG0)
Putative heat shock protein HSP 90-alpha A5 (Heat shock protein 90-alpha E) (Heat shock protein 90Ae)
Gene: HSP90AA5P

Interactor 2: KS6B2 (Q9UBS0)
Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta)
Gene: RPS6KB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 334 Hs			1 482
+	Hs
		1123514 HS905_HUMAN (1-334): 1.88e-109: 323: 100.00		AKT3_HUMAN (6-391): 7.6e-154: 447: 39.85
+	Hs
		969092 H90B2_HUMAN (21-280): 5.42e-80: 250: 55.13		KPCE_HUMAN (2-395): 2.02e-145: 435: 34.23
+	Hs
		1123447 H90B4_HUMAN (22-280): 3.47e-71: 231: 33.53		AKT3_HUMAN (6-391): 7.6e-154: 447: 39.85
+	Hs
		1162538 Q6PK50_HUMAN (22-160): 1.23e-47: 165: 65.49		AKT3_HUMAN (6-391): 7.6e-154: 447: 39.85
+	Hs
		437905 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		KS6B1_HUMAN (1-476): 3.36e-173: 499: 68.58
+	Hs
		272877 HS905_HUMAN (1-334): 1.88e-109: 323: 100.00		KS6A4_HUMAN (39-450): 2.95e-78: 261: 24.07
+	Hs
		1073431 H90B2_HUMAN (21-280): 5.42e-80: 250: 55.13		KS6A1_HUMAN (5-380): 2.15e-105: 331: 25.19
+	Hs
		850666 H90B2_HUMAN (21-280): 5.42e-80: 250: 55.13		KS6A3_HUMAN (5-380): 2.45e-105: 331: 26.85
+	Mm
		432411 HS90A_MOUSE (22-160): 8.73e-22: 98.2: 73.97		AKT1_MOUSE (5-391): 1.98e-153: 447: 39.44
+	Mm
		513660 HS90B_MOUSE (22-160): 9.09e-22: 98.2: 65.49		AKT1_MOUSE (5-391): 1.98e-153: 447: 39.44
+	Rn
		812703 HS90A_RAT (22-160): 8.65e-22: 98.2: 73.97		AKT1_RAT (5-391): 3.1e-153: 446: 39.19
+	Hs
		1123464 H90B3_HUMAN (230-330): 2.48e-21: 96.7: 40.78		AKT3_HUMAN (6-391): 7.6e-154: 447: 39.85
+	Bt
		964601 HS90B_BOVIN (22-160): 8.99e-21: 95.2: 64.79		AKT1_BOVIN (5-391): 7.12e-154: 448: 39.70
+	Hs
		681885 H90B3_HUMAN (230-330): 2.48e-21: 96.7: 40.78		AKT1_HUMAN (5-391): 6.01e-153: 445: 39.19
+	Hs
		437869 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		KPCA_HUMAN (9-401): 2.4e-148: 440: 35.82
+	Hs
		437870 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		KAPCA_HUMAN (31-387): 1.3e-144: 419: 34.17
+	Hs
		272876 H90B4_HUMAN (22-280): 3.47e-71: 231: 33.53		KS6A4_HUMAN (39-450): 2.95e-78: 261: 24.07
+	Hs
		270364 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		KS6A5_HUMAN (2-325): 6.86e-97: 311: 23.32
+	Hs
		116958 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		SGK1_HUMAN (55-393): 4e-100: 308: 47.03
+	Hs
		272844 HS90B_HUMAN (22-160): 8.04e-21: 95.2: 64.79		KS6A4_HUMAN (39-450): 2.95e-78: 261: 24.07