HitPredict

Interactor 1: Q59GL9 (Q59GL9)
IkappaB kinase (EC 2.7.11.10)
Gene: Q59GL9

Interactor 2: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 483 Hs			1 351
+	Hs
		158374 IKKB_HUMAN (2-469): 5.76e-132: 401: 94.23		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		158371 IKKB_HUMAN (2-469): 5.76e-132: 401: 94.23		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		1123982 Q59GT1_HUMAN (2-481): 5.33e-127: 387: 53.73		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Hs
		167449 IKKA_HUMAN (2-481): 4.28e-126: 385: 53.73		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431932 Q59GT1_HUMAN (2-481): 5.33e-127: 387: 53.73		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		167446 IKKA_HUMAN (2-481): 4.28e-126: 385: 53.73		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Rn
		709234 AAPK1_RAT (1-436): 1.4e-93: 296: 20.09		HS90B_RAT (1-345): 1.63e-176: 509: 99.71
+	Hs
		438123 AAPK1_HUMAN (1-436): 1.63e-93: 296: 20.09		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		438164 IKKE_HUMAN (11-333): 3.63e-91: 294: 26.71		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		1050223 IKKE_HUMAN (11-333): 3.63e-91: 294: 26.71		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Rn
		871252 AAPK1_RAT (1-436): 1.4e-93: 296: 20.09		HS90A_RAT (1-350): 4.7e-174: 503: 84.40
+	Hs
		431800 AAPK1_HUMAN (1-436): 1.63e-93: 296: 20.09		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		431843 IKKE_HUMAN (11-333): 3.63e-91: 294: 26.71		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Zm
		24080 A0A1D6ICZ3_MAIZE (2-435): 1.22e-125: 377: 14.81		A0A1D6LMW9_MAIZE (5-348): 2.19e-139: 416: 50.43
+	Hs
		438593 TBK1_HUMAN (2-321): 1.19e-87: 285: 26.87		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		432334 TBK1_HUMAN (2-321): 1.19e-87: 285: 26.87		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		432166 KCC1G_HUMAN (9-241): 4.36e-74: 242: 25.32		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Zm
		35496 A0A1D6QH07_MAIZE (2-400): 3.5e-99: 307: 17.02		A0A1D6LMW9_MAIZE (5-348): 2.19e-139: 416: 50.43
+	Rn
		871301 AAPK1_RAT (1-436): 1.4e-93: 296: 20.09		ENPL_RAT (2-351): 8.26e-142: 422: 42.25
+	Sc
		365561 SNF1_YEAST (6-324): 3.5e-86: 279: 25.68		HSP82_YEAST (11-350): 7.63e-148: 435: 66.86