HitPredict

Interactor 1: Q59GL9 (Q59GL9)
IkappaB kinase (EC 2.7.11.10)
Gene: Q59GL9

Interactor 2: Q9BPW0 (Q9BPW0)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 483 Hs			1 484
+	Hs
		1123983 Q59GT1_HUMAN (2-481): 5.33e-127: 387: 53.73		Q9BPW0_HUMAN (1-484): 0: 546: 100.00
+	Hs
		158442 IKKB_HUMAN (2-469): 5.76e-132: 401: 94.23		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		158435 IKKB_HUMAN (2-469): 5.76e-132: 401: 94.23		PP4C_HUMAN (185-483): 1.17e-165: 471: 39.33
+	Hs
		167515 IKKA_HUMAN (2-481): 4.28e-126: 385: 53.73		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		167506 IKKA_HUMAN (2-481): 4.28e-126: 385: 53.73		PP4C_HUMAN (185-483): 1.17e-165: 471: 39.33
+	Hs
		158438 IKKB_HUMAN (2-469): 5.76e-132: 401: 94.23		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25
+	Mm
		291448 IKKB_MOUSE (2-469): 1.22e-130: 397: 87.61		PP1A_MOUSE (196-479): 1.86e-152: 438: 38.25
+	Hs
		167511 IKKA_HUMAN (2-481): 4.28e-126: 385: 53.73		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		167510 IKKA_HUMAN (2-481): 4.28e-126: 385: 53.73		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25
+	Rn
		871244 AAPK1_RAT (1-436): 1.4e-93: 296: 20.09		PP2AA_RAT (188-483): 3.95e-169: 480: 40.33
+	Hs
		930826 AAPK1_HUMAN (1-436): 1.63e-93: 296: 20.09		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		930841 KCC1A_HUMAN (6-272): 4.25e-93: 288: 23.22		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		890962 IKKE_HUMAN (11-333): 3.63e-91: 294: 26.71		PP4C_HUMAN (185-483): 1.17e-165: 471: 39.33
+	Dm
		1359353 Q9V3Y8_DROME (2-306): 3.92e-76: 254: 26.02		Q9VH81_DROME (2-482): 1.01e-173: 500: 59.79
+	Mm
		956533 TBK1_MOUSE (2-321): 2.33e-86: 281: 26.57		PP4C_MOUSE (185-483): 1.17e-165: 471: 39.33
+	Hs
		915188 IKKE_HUMAN (11-333): 3.63e-91: 294: 26.71		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Rn
		871210 AAPK1_RAT (1-436): 1.4e-93: 296: 20.09		PP1A_RAT (196-479): 3.63e-152: 438: 38.25
+	Sc
		419841 SNF1_YEAST (6-324): 3.5e-86: 279: 25.68		PP12_YEAST (195-479): 6.55e-149: 429: 39.51
+	Hs
		858650 ULK2_HUMAN (19-176): 2.67e-26: 114: 40.24		PPP5_HUMAN (1-482): 0: 546: 99.17
+	Hs
		262251 ULK1_HUMAN (19-173): 1.07e-25: 113: 39.13		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25