HitPredict

Interactor 1: Q59GT1 (Q59GT1)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (EC 2.7.11.10) (Nuclear factor NF-kappa-B inhibitor kinase alpha)
Gene: Q59GT1

Interactor 2: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 726 Hs			1 351
+	Hs
		431932 Q59GT1_HUMAN (1-726): 0: 636: 100.00		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		167449 IKKA_HUMAN (8-710): 0: 587: 100.00		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		167446 IKKA_HUMAN (8-710): 0: 587: 100.00		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		158374 IKKB_HUMAN (8-697): 0: 561: 52.14		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		158371 IKKB_HUMAN (8-697): 0: 561: 52.14		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438465 M3K5_HUMAN (21-698): 2.88e-128: 415: 19.26		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		432196 M3K5_HUMAN (21-698): 2.88e-128: 415: 19.26		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		1123962 Q59GL9_HUMAN (74-521): 2.14e-130: 396: 56.73		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Hs
		437908 CDK2_HUMAN (19-319): 1.61e-125: 377: 22.98		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431549 CDK2_HUMAN (19-319): 1.61e-125: 377: 22.98		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438593 TBK1_HUMAN (22-514): 1.31e-109: 350: 23.15		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		438585 KS6B2_HUMAN (22-422): 4.14e-112: 349: 21.45		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		432334 TBK1_HUMAN (22-514): 1.31e-109: 350: 23.15		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		432326 KS6B2_HUMAN (22-422): 4.14e-112: 349: 21.45		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438164 IKKE_HUMAN (22-618): 2.17e-90: 299: 21.46		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		1050223 IKKE_HUMAN (22-618): 2.17e-90: 299: 21.46		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Hs
		431843 IKKE_HUMAN (22-618): 2.17e-90: 299: 21.46		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		538107 CDK2_HUMAN (19-319): 1.61e-125: 377: 22.98		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Zm
		35496 A0A1D6QH07_MAIZE (11-455): 1.35e-121: 373: 18.41		A0A1D6LMW9_MAIZE (5-348): 2.19e-139: 416: 50.43
+	Hs
		431511 KAPCA_HUMAN (1-323): 2.04e-89: 285: 26.67		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92