HitPredict

Interactor 1: M9ND00 (M9ND00)
Dynamin associated protein 160, isoform D
Gene: Dap160

Interactor 2: DYN (P27619)
Dynamin (EC 3.6.5.5) (Protein shibire) (dDyn)
Gene: shi

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	18701694, 23321638, 24977345, 9668096, 10918586, 11711432, 14622578, 26538647
Identification Methods	affinity chromatography technology, far western blotting, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0048488 - synaptic vesicle endocytosis GO:0150007 - clathrin-dependent synaptic vesicle endocytosis GO:0150008 - bulk synaptic vesicle endocytosis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1190 Dm			1 877
+	Hs
		840840 ITSN2_HUMAN (1-1177): 2.21e-115: 396: 27.22		DYN2_HUMAN (1-849): 0: 1005: 65.06
+	Hs
		983379 ITSN1_HUMAN (3-1101): 6.35e-106: 369: 25.06		DYN1_HUMAN (1-844): 0: 1018: 65.52
+	Mm
		760469 ITSN1_MOUSE (3-1101): 5.94e-103: 361: 25.19		DYN1_MOUSE (1-838): 0: 1020: 65.74
+	Hs
		840702 ITSN1_HUMAN (3-1101): 6.35e-106: 369: 25.06		DYN2_HUMAN (1-849): 0: 1005: 65.06
+	Rn
		599413 ITSN1_RAT (3-1185): 3.77e-103: 361: 23.49		DYN1_RAT (1-844): 0: 1012: 65.52
+	Mm
		760488 ITSN1_MOUSE (3-1101): 5.94e-103: 361: 25.19		DYN2_MOUSE (1-832): 0: 1008: 67.06
+	Dm
		91155 E3CTP7_DROME (8-507): 9.96e-62: 228: 21.06		DYN_DROME (1-877): 0: 1132: 100.00
+	Dm
		247616 O61618_DROME (560-1183): 7.91e-16: 85.2: 10.42		DYN_DROME (1-877): 0: 1132: 100.00
+	Hs
		787872 EPS15_HUMAN (2-415): 6.88e-36: 149: 13.53		DYN2_HUMAN (1-849): 0: 1005: 65.06
+	Hs
		840719 SH319_HUMAN (744-1084): 2.09e-29: 128: 16.62		DYN2_HUMAN (1-849): 0: 1005: 65.06
+	Mm
		223006 NCK2_MOUSE (676-912): 3.86e-20: 96.1: 20.75		DYN1_MOUSE (1-838): 0: 1020: 65.74
+	Hs
		557664 NCK1_HUMAN (670-935): 3.89e-19: 92.8: 16.55		DYN1_HUMAN (1-844): 0: 1018: 65.52
+	Mm
		760462 SH3K1_MOUSE (658-1029): 2.21e-15: 83.4: 12.63		DYN1_MOUSE (1-838): 0: 1020: 65.74
+	Hs
		840747 SH3R1_HUMAN (669-1076): 1.68e-18: 93.7: 12.64		DYN2_HUMAN (1-849): 0: 1005: 65.06
+	Hs
		983399 SH3K1_HUMAN (1025-1087): 1.01e-12: 74.6: 39.68		DYN1_HUMAN (1-844): 0: 1018: 65.52
+	Mm
		760481 SH3K1_MOUSE (658-1029): 2.21e-15: 83.4: 12.63		DYN2_MOUSE (1-832): 0: 1008: 67.06
+	Hs
		840878 CD2AP_HUMAN (626-731): 1.49e-13: 77.3: 21.24		DYN2_HUMAN (1-849): 0: 1005: 65.06
+	Hs
		840786 SH3K1_HUMAN (1025-1087): 1.01e-12: 74.6: 39.68		DYN2_HUMAN (1-849): 0: 1005: 65.06
+	Ce
		760510 Q9U2T9_CAEEL (623-1105): 1.07e-11: 71.7: 11.34		DYN1_CAEEL (1-759): 0: 981: 68.51