HitPredict

Interactor 1: BCORL (Q5H9F3)
BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1)
Gene: BCORL1

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Property	Details
Experiments	24981860, 26687479, 27705803, 27505670, 32628469, 33961781, 22325352, 23523425
Identification Methods	affinity chromatography technology, two hybrid, pull down, molecular sieving, lambda repressor two hybrid, x-ray crystallography, ion exchange chromatography, cosedimentation in solution, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PUFD~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1785 Hs			1 259
+	Hs
		717904 BCORL_HUMAN (1-1785): 7.14e-132: 456: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		718403 BCORL_HUMAN (1-1785): 7.14e-132: 456: 100.00		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		1108508 BCORL_HUMAN (1-1785): 7.14e-132: 456: 100.00		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Hs
		1125901 BCORL_HUMAN (1-1785): 7.14e-132: 456: 100.00		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		1125882 BCORL_HUMAN (1-1785): 7.14e-132: 456: 100.00		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Hs
		1125897 BCORL_HUMAN (1-1785): 7.14e-132: 456: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1167299 BCOR_HUMAN (1-1780): 6.52e-94: 340: 21.03		PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00
+	Hs
		987979 BCORL_HUMAN (1-1785): 7.14e-132: 456: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		717948 BCOR_HUMAN (1-1780): 6.52e-94: 340: 21.03		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		718405 BCOR_HUMAN (1-1780): 6.52e-94: 340: 21.03		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Hs
		1108510 BCOR_HUMAN (1-1780): 6.52e-94: 340: 21.03		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Mm
		1208443 BCOR_MOUSE (1-1780): 1.53e-101: 364: 20.71		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Hs
		1167302 BCOR_HUMAN (1-1780): 6.52e-94: 340: 21.03		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		1167255 BCOR_HUMAN (1-1780): 6.52e-94: 340: 21.03		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Hs
		1167292 BCOR_HUMAN (1-1780): 6.52e-94: 340: 21.03		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		987982 BCOR_HUMAN (1-1780): 6.52e-94: 340: 21.03		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		1206042 MIB1_HUMAN (1269-1645): 3.5e-45: 180: 14.68		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Hs
		1021448 ANK3_HUMAN (1503-1781): 1.17e-45: 184: 16.31		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		282720 BARD1_HUMAN (1207-1613): 4.5e-63: 233: 22.92		RNF8_HUMAN (24-130): 3e-10: 61.7: 28.04
+	Dm
		1214938 Q8IQT4_DROME (187-646): 1.63e-09: 65.3: 16.73		Q9VV77_DROME (32-257): 1.29e-53: 174: 39.30