HitPredict

Interactor 1: RNC (Q5HZJ0)
Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III)
Gene: Drosha

Interactor 2: Q8BTS0 (Q8BTS0)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5)
Gene: Ddx5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25963660
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Helicase_C~dsrm, DEAD~Ribonuclease_3
Common GO terms	GO:0005730 - nucleolus GO:0031053 - primary miRNA processing GO:0070412 - R-SMAD binding GO:0070878 - primary miRNA binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1373 Mm			1 615
+	Hs
		571611 RNC_HUMAN (1-1373): 0: 1315: 95.56		DDX5_HUMAN (1-615): 0: 609: 98.86
+	Mm
		1119382 RNC_MOUSE (1-1373): 0: 1313: 100.00		DDX17_MOUSE (30-613): 0: 529: 67.37
+	Hs
		1271678 RNC_HUMAN (1-1373): 0: 1315: 95.56		DDX17_HUMAN (30-613): 2.43e-179: 527: 67.54
+	Hs
		571417 EP300_HUMAN (13-371): 3.21e-11: 70.7: 10.50		DDX5_HUMAN (1-615): 0: 609: 98.86
+	Hs
		571635 DICER_HUMAN (1112-1196): 2.61e-11: 70.7: 31.46		DDX5_HUMAN (1-615): 0: 609: 98.86
+	Hs
		1271697 DICER_HUMAN (1112-1196): 2.61e-11: 70.7: 31.46		DDX17_HUMAN (30-613): 2.43e-179: 527: 67.54
+	Hs
		998944 EP300_HUMAN (13-371): 3.21e-11: 70.7: 10.50		DDX17_HUMAN (30-613): 2.43e-179: 527: 67.54
+	Hs
		998860 EP300_HUMAN (13-371): 3.21e-11: 70.7: 10.50		DDX42_HUMAN (7-614): 2.05e-154: 469: 33.92
+	Hs
		134001 EP300_HUMAN (13-371): 3.21e-11: 70.7: 10.50		DDX3X_HUMAN (3-478): 1.97e-148: 445: 38.66
+	Hs
		998835 EP300_HUMAN (13-371): 3.21e-11: 70.7: 10.50		DDX46_HUMAN (50-477): 2.27e-108: 351: 40.68