HitPredict

Interactor 1: RNFT1 (Q5M7Z0)
E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1)
Gene: RNFT1

Interactor 2: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 321
+	Hs
		1138884 SYVN1_HUMAN (137-419): 2.63e-64: 219: 13.84		UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00
+	Hs
		919742 RNFT1_HUMAN (1-435): 5.27e-156: 450: 100.00		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		895804 RNFT1_HUMAN (1-435): 5.27e-156: 450: 100.00		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		610432 CBL_HUMAN (147-433): 7.09e-43: 163: 13.64		UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00
+	Hs
		1138894 RN139_HUMAN (169-429): 2.94e-42: 160: 15.00		UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00
+	Hs
		919766 SYVN1_HUMAN (137-419): 2.63e-64: 219: 13.84		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		895831 SYVN1_HUMAN (137-419): 2.63e-64: 219: 13.84		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		1356614 AMFR_HUMAN (137-416): 2.16e-48: 176: 15.33		UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33
+	Hs
		849484 AMFR_HUMAN (137-416): 2.16e-48: 176: 15.33		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		919902 AMFR_HUMAN (137-416): 2.16e-48: 176: 15.33		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		895950 AMFR_HUMAN (137-416): 2.16e-48: 176: 15.33		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		610305 CBL_HUMAN (147-433): 7.09e-43: 163: 13.64		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		610333 CBL_HUMAN (147-433): 7.09e-43: 163: 13.64		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		610323 CBL_HUMAN (147-433): 7.09e-43: 163: 13.64		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Sc
		549841 HRD1_YEAST (137-419): 9.43e-43: 160: 13.55		UBC4_YEAST (1-152): 1.07e-73: 225: 28.95
+	Mm
		895981 CBLB_MOUSE (138-426): 9.14e-39: 151: 12.13		UB2D1_MOUSE (4-153): 1.02e-75: 230: 30.00
+	Hs
		610481 CBL_HUMAN (147-433): 7.09e-43: 163: 13.64		UB2E2_HUMAN (3-153): 5.78e-68: 212: 23.18
+	Hs
		610469 CBL_HUMAN (147-433): 7.09e-43: 163: 13.64		UB2E3_HUMAN (3-153): 1.57e-67: 211: 24.50
+	Hs
		610307 CBL_HUMAN (147-433): 7.09e-43: 163: 13.64		UB2E1_HUMAN (3-153): 1.32e-66: 209: 25.17
+	Mm
		1112075 CBLB_MOUSE (138-426): 9.14e-39: 151: 12.13		UBE2C_MOUSE (9-155): 2.67e-20: 88.2: 31.29