Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.998

The method score is based on:

Property Details
Experiments 24510904, 26375402, 30858560, 17260967, 20515039, 16269541, 17584768, 20595391, 22423108, 22952686, 21159966, 20090955, 19559761, 19545277, 19826009, 18397888, 19302196, 22612223, 21806997, 21858031 and 41 others

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Identification Methods enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, two hybrid, protein kinase assay, blue native page, dynamic light scattering, cross-linking study, kinase scintillation proximity assay and 4 others

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Interaction Type direct interaction, physical association, association, phosphorylation reaction, self interaction

The annotation score is based on:

Property Details
Interacting Pfam domains COR~COR, COR~Roc, LRR_8~LRR_8, Pkinase~Pkinase, Roc~Roc
Common GO terms GO:0000139 - Golgi membrane
GO:0000149 - SNARE binding
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0001933 - negative regulation of protein phosphorylation
and 156 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 2527
Hs

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Last updated: 15 Jul 2024