Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2
Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.99 | 1.00 | 0.998 |
The method score is based on:
Property | Details |
---|---|
Experiments | 24510904, 26375402, 30858560, 17260967, 20515039, 16269541, 17584768, 20595391, 22423108, 22952686, 21159966, 20090955, 19559761, 19545277, 19826009, 18397888, 19302196, 22612223, 21806997, 21858031 and 41 others
more... |
Identification Methods | enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, two hybrid, protein kinase assay, blue native page, dynamic light scattering, cross-linking study, kinase scintillation proximity assay and 4 others
more... |
Interaction Type | direct interaction, physical association, association, phosphorylation reaction, self interaction |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | COR~COR, COR~Roc, LRR_8~LRR_8, Pkinase~Pkinase, Roc~Roc |
Common GO terms | GO:0000139 - Golgi membrane GO:0000149 - SNARE binding GO:0000165 - MAPK cascade GO:0000287 - magnesium ion binding GO:0001933 - negative regulation of protein phosphorylation and 156 others more... |
Homologous interactions | 19 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024