HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 975
+	Hs
		256275 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		BRE1B_HUMAN (1-974): 4.61e-62: 230: 56.49
+	Hs
		1130714 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		MYH2_HUMAN (201-955): 6.17e-36: 150: 13.16
+	Hs
		724862 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		254486 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		ROCK2_HUMAN (96-897): 2.15e-15: 83.5: 14.08
+	Hs
		148910 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		725175 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		MYH10_HUMAN (604-944): 1.39e-12: 74.4: 10.85
+	Hs
		551732 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		DESP_HUMAN (225-919): 9.01e-12: 71.9: 16.12
+	Mm
		1130117 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		MYH9_MOUSE (1-355): 3.58e-12: 72.9: 10.31