HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31046837, unassigned1853
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005783 - endoplasmic reticulum GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 999
+	Hs
		1130390 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320869 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		714249 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		1130801 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		V9HW22_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		504206 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		2872 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0A0G2JIW1_HUMAN (682-813): 3.06e-30: 129: 16.67
+	Hs
		483766 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		HS71A_HUMAN (682-813): 3.35e-30: 129: 16.67
+	Hs
		782813 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		714124 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		503596 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		564025 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		HSP76_HUMAN (682-813): 1.1e-27: 121: 19.70
+	Hs
		504171 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		201242 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		HS71L_HUMAN (682-814): 9.92e-31: 131: 15.04
+	Hs
		201190 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		201280 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		HSP72_HUMAN (682-814): 8.57e-30: 128: 16.54
+	At
		612329 BRL2_ARATH (1470-1771): 1.68e-09: 65.8: 10.33		HS701_ARATH (480-814): 2.69e-30: 129: 11.92