HitPredict

Interactor 1: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Interactor 2: KCTD3 (Q9Y597)
BTB/POZ domain-containing protein KCTD3 (Renal carcinoma antigen NY-REN-45)
Gene: KCTD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 815
+	Hs
		1020242 PTN13_HUMAN (72-497): 1.88e-29: 125: 12.84		KCTD3_HUMAN (1-815): 0: 1392: 100.00
+	Hs
		153961 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		KCTD3_HUMAN (1-815): 0: 1392: 100.00
+	Hs
		1300703 MAGI1_HUMAN (183-460): 1.21e-20: 98.3: 19.89		KCTD3_HUMAN (1-815): 0: 1392: 100.00
+	Hs
		1132910 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		SHKB1_HUMAN (14-661): 0: 1005: 65.46
+	Hs
		153935 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		SHKB1_HUMAN (14-661): 0: 1005: 65.46
+	Hs
		1132926 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		KCTD5_HUMAN (3-185): 7.92e-44: 160: 25.48
+	Hs
		1057225 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		KCTD2_HUMAN (11-185): 1.92e-38: 145: 28.36
+	Hs
		1132909 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		KCD17_HUMAN (18-180): 2.26e-36: 141: 32.62
+	Hs
		942389 DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22		KCND2_HUMAN (1-149): 2.25e-38: 154: 25.93
+	Mm
		1143350 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		KCD12_MOUSE (11-175): 1.91e-35: 139: 24.86
+	Hs
		1057230 DLG3_HUMAN (3-359): 3.36e-32: 133: 17.27		KCTD2_HUMAN (11-185): 1.92e-38: 145: 28.36
+	Hs
		153954 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		KCTD5_HUMAN (3-185): 7.92e-44: 160: 25.48
+	Hs
		1174576 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		KCTD1_HUMAN (8-183): 6.49e-43: 158: 21.86
+	Hs
		153919 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		KCTD2_HUMAN (11-185): 1.92e-38: 145: 28.36
+	Hs
		1252368 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		BACD1_HUMAN (8-149): 1.78e-36: 142: 27.52
+	Hs
		1235348 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		KCD17_HUMAN (18-180): 2.26e-36: 141: 32.62
+	Hs
		1252409 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		KCTD7_HUMAN (8-125): 5.48e-36: 139: 31.36
+	Hs
		1045929 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		BACD2_HUMAN (2-149): 5.47e-35: 137: 25.66
+	Hs
		1241184 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		KCTD6_HUMAN (17-109): 7.95e-30: 120: 45.26
+	Hs
		1183868 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		KCTD9_HUMAN (17-111): 6.71e-24: 106: 36.36