HitPredict

Interactor 1: Q5T3G3 (Q5T3G3)
TLE family member 1, transcriptional corepressor
Gene: TLE1

Interactor 2: SIX2 (Q9NPC8)
Homeobox protein SIX2 (Sine oculis homeobox homolog 2)
Gene: SIX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 291
+	Hs
		980654 TLE1_HUMAN (1-242): 2.27e-134: 398: 95.87		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		980881 TLE3_HUMAN (1-242): 7.56e-115: 347: 68.85		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		315169 TLE1_HUMAN (1-242): 2.27e-134: 398: 95.87		SIX6_HUMAN (1-241): 6.29e-75: 231: 55.92
+	Hs
		311439 TLE1_HUMAN (1-242): 2.27e-134: 398: 95.87		SIX3_HUMAN (1-245): 4.52e-71: 224: 57.43
+	Hs
		980756 TLE3_HUMAN (1-242): 7.56e-115: 347: 68.85		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Hs
		315171 TLE4_HUMAN (1-242): 7.41e-123: 368: 76.45		SIX6_HUMAN (1-241): 6.29e-75: 231: 55.92
+	Mm
		1143691 TLE4_MOUSE (1-242): 3.85e-123: 369: 76.45		SIX3_MOUSE (1-245): 3.44e-71: 224: 57.43
+	Mm
		1143964 TLE4_MOUSE (1-242): 3.85e-123: 369: 76.45		SIX6_MOUSE (1-241): 3.05e-72: 224: 55.51
+	Hs
		315170 TLE3_HUMAN (1-242): 7.56e-115: 347: 68.85		SIX6_HUMAN (1-241): 6.29e-75: 231: 55.92
+	Hs
		822627 TLE1_HUMAN (1-242): 2.27e-134: 398: 95.87		LHX1_HUMAN (21-291): 4.37e-42: 151: 14.52
+	Hs
		980622 TLE1_HUMAN (1-242): 2.27e-134: 398: 95.87		LHX8_HUMAN (19-283): 1.39e-40: 146: 15.83
+	Hs
		620142 TLE1_HUMAN (1-242): 2.27e-134: 398: 95.87		PAX7_HUMAN (100-285): 8.75e-35: 133: 19.89
+	Hs
		839732 TLE1_HUMAN (1-242): 2.27e-134: 398: 95.87		LHX2_HUMAN (26-258): 1.9e-35: 133: 16.72
+	Dm
		558378 GROU_DROME (1-241): 1.29e-90: 283: 50.62		SO_DROME (4-257): 1.39e-74: 235: 64.98
+	Hs
		620144 TLE4_HUMAN (1-242): 7.41e-123: 368: 76.45		PAX7_HUMAN (100-285): 8.75e-35: 133: 19.89
+	Hs
		620143 TLE3_HUMAN (1-242): 7.56e-115: 347: 68.85		PAX7_HUMAN (100-285): 8.75e-35: 133: 19.89
+	Mm
		623700 TLE4_MOUSE (1-242): 3.85e-123: 369: 76.45		PAX3_MOUSE (123-285): 8.92e-27: 110: 18.94
+	Dm
		558386 GROU_DROME (1-241): 1.29e-90: 283: 50.62		OPTIX_DROME (4-255): 1.87e-58: 195: 44.53
+	Hs
		764630 TLE4_HUMAN (1-242): 7.41e-123: 368: 76.45		CUX1_HUMAN (136-259): 8.94e-10: 61.3: 24.49
+	Hs
		764629 TLE3_HUMAN (1-242): 7.56e-115: 347: 68.85		CUX1_HUMAN (136-259): 8.94e-10: 61.3: 24.49