HitPredict

Interactor 1: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	21903422
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 861 Hs			1 540
+	Hs
		1190062 ITCH_HUMAN (318-855): 0: 545: 17.83		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		1190096 SMUF2_HUMAN (336-855): 3.41e-177: 531: 20.32		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		1190099 SMUF1_HUMAN (336-855): 2.1e-167: 506: 17.88		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Mm
		1208048 ITCH_MOUSE (318-855): 0: 544: 17.83		MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68
+	Mm
		1257422 SMUF1_MOUSE (363-855): 4.54e-172: 517: 18.96		MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68
+	Hs
		554367 WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67		MUC1_HUMAN (160-534): 7.43e-16: 83.3: 10.90
+	Hs
		1192113 HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78		HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36
+	Hs
		125274 WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74		SC24C_HUMAN (116-429): 9.64e-11: 66.7: 15.43
+	Dm
		1374363 SUDX_DROME (321-855): 1.97e-164: 504: 16.79		Q9VUH6_DROME (84-466): 1.74e-10: 65.9: 16.62
+	Hs
		1192175 HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58
+	Hs
		1295414 HECW2_HUMAN (336-855): 4.75e-146: 471: 20.34		CHAP1_HUMAN (196-539): 2.7e-10: 65.2: 10.38
+	Hs
		1170093 HECW2_HUMAN (336-855): 4.75e-146: 471: 20.34		SRCAP_HUMAN (88-342): 3.17e-09: 62.1: 16.86
+	Sc
		758550 TOM1_YEAST (436-849): 1.84e-118: 398: 23.61		SEC31_YEAST (78-518): 5.47e-22: 102: 13.94
+	Hs
		319899 HERC2_HUMAN (237-372): 5.72e-44: 175: 35.77		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		319840 HERC2_HUMAN (237-372): 5.72e-44: 175: 35.77		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48
+	Hs
		1061491 CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63		CORA1_HUMAN (42-516): 9.85e-18: 89.5: 16.07
+	Hs
		1056833 CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63		MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48