HitPredict

Interactor 1: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Interactor 2: EGFL6 (Q8IUX8)
Epidermal growth factor-like protein 6 (EGF-like protein 6) (MAM and EGF domains-containing gene protein)
Gene: EGFL6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 861 Hs			1 553
+	Dm
		422918 NEDD4_DROME (372-852): 3.31e-176: 537: 19.47		NOTCH_DROME (62-417): 1.15e-25: 114: 15.39
+	Dm
		247208 NEDD4_DROME (372-852): 3.31e-176: 537: 19.47		TENM_DROME (2-195): 1.27e-23: 108: 13.74
+	Hs
		125785 WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74		NOTC3_HUMAN (66-283): 2.24e-24: 110: 21.21
+	Mm
		966330 ITCH_MOUSE (318-855): 0: 544: 17.83		NOTC1_MOUSE (3-369): 3.75e-16: 84.6: 14.41
+	Dm
		422970 SUDX_DROME (321-855): 1.97e-164: 504: 16.79		NOTCH_DROME (62-417): 1.15e-25: 114: 15.39
+	Hs
		804164 NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46		NOTC1_HUMAN (5-285): 5.22e-11: 68: 14.01
+	Hs
		804318 ITCH_HUMAN (318-855): 0: 545: 17.83		NOTC1_HUMAN (5-285): 5.22e-11: 68: 14.01
+	Hs
		328037 NED4L_HUMAN (374-853): 1.61e-171: 524: 19.11		FBLN4_HUMAN (17-184): 2.32e-15: 80.5: 19.25
+	Hs
		804323 NED4L_HUMAN (374-853): 1.61e-171: 524: 19.11		NOTC1_HUMAN (5-285): 5.22e-11: 68: 14.01
+	Hs
		804337 WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67		NOTC1_HUMAN (5-285): 5.22e-11: 68: 14.01
+	Hs
		1059037 SMUF1_HUMAN (336-855): 2.1e-167: 506: 17.88		LTBP1_HUMAN (17-251): 8.54e-10: 64: 20.85
+	Dm
		246947 SMUF1_DROME (466-855): 2.38e-140: 444: 21.43		TENM_DROME (2-195): 1.27e-23: 108: 13.74
+	Dm
		247320 Q9W325_DROME (440-855): 2.61e-147: 442: 19.07		TENM_DROME (2-195): 1.27e-23: 108: 13.74
+	Ce
		107923 Q9GUP2_CAEEL (430-850): 4.89e-115: 389: 21.95		G5EFX3_CAEEL (105-251): 1.11e-09: 63.5: 32.67
+	Hs
		1061662 CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63		FBLN5_HUMAN (47-264): 1.54e-20: 96.3: 32.07
+	Hs
		1219338 CUL9_HUMAN (245-370): 1.19e-18: 94: 40.63		LTBP4_HUMAN (49-247): 1.47e-11: 69.7: 32.88
+	Hs
		195717 ZZEF1_HUMAN (233-369): 8.7e-18: 91.3: 34.06		EGFL6_HUMAN (2-165): 5.98e-12: 70.3: 15.93