HitPredict

Interactor 1: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Interactor 2: TCPH (Q99832)
T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (Chaperonin containing T-complex polypeptide 1 subunit 7) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]
Gene: CCT7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 861 Hs			1 543
+	Hs
		573298 HECD3_HUMAN (1-861): 0: 1137: 100.00		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Hs
		843235 HECD3_HUMAN (1-861): 0: 1137: 100.00		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79
+	Hs
		1306694 SMUF1_HUMAN (336-855): 2.1e-167: 506: 17.88		TCPH_HUMAN (1-543): 0: 647: 100.00
+	Hs
		1192186 HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78		TCPH_HUMAN (1-543): 0: 647: 100.00
+	Hs
		125246 WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		125243 WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		826741 HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		821288 HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		573490 SMUF1_HUMAN (336-855): 2.1e-167: 506: 17.88		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Hs
		573339 HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Sc
		792404 TOM1_YEAST (436-849): 1.84e-118: 398: 23.61		TCPH_YEAST (2-542): 0: 587: 62.45
+	Sc
		772921 TOM1_YEAST (436-849): 1.84e-118: 398: 23.61		TCPE_YEAST (2-526): 0: 568: 29.98
+	Sc
		760801 TOM1_YEAST (436-849): 1.84e-118: 398: 23.61		TCPG_YEAST (2-527): 0: 546: 30.68
+	Hs
		843398 SMUF1_HUMAN (336-855): 2.1e-167: 506: 17.88		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79
+	Hs
		843265 HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79
+	Hs
		1072710 UBE3C_HUMAN (495-845): 2.66e-20: 99: 27.64		TCPH_HUMAN (1-543): 0: 647: 100.00
+	Hs
		826666 CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63		TCPG_HUMAN (1-541): 0: 577: 31.09
+	Hs
		821216 CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63		TCPE_HUMAN (3-527): 0: 557: 29.59
+	Hs
		573264 CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63		TCPA_HUMAN (2-533): 0: 544: 34.54
+	Hs
		843200 CUL7_HUMAN (245-370): 1.55e-18: 93.6: 40.63		TCPD_HUMAN (24-520): 4.05e-90: 288: 33.79