Interactor 1: EMC2 (Q15006)
ER membrane protein complex subunit 2 (Tetratricopeptide repeat protein 35) (TPR repeat protein 35)
Gene: EMC2

Interactor 2: EMC5 (Q8N4V1)
ER membrane protein complex subunit 5 (Membrane magnesium transporter 1) (Transmembrane protein 32)
Gene: MMGT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.90 0.923

The method score is based on:

Property Details
Experiments 22119785, 26496610, 27342126, 33961781, 35271311, 26186194, 28514442, 31839598, 32439656
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains MMgT~TPR_EMC2
Common GO terms GO:0005789 - endoplasmic reticulum membrane
GO:0045050 - protein insertion into ER membrane by stop-transfer membrane-anchor sequence
GO:0071816 - tail-anchored membrane protein insertion into ER membrane
GO:0072546 - EMC complex
Homologous interactions 0

Service provided by Combinatics, Japan

Last updated: 11Aug2025