HitPredict

Interactor 1: MAGI3 (Q5TCQ9)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (Membrane-associated guanylate kinase inverted 3) (MAGI-3)
Gene: MAGI3

Interactor 2: NRCAM (Q92823)
Neuronal cell adhesion molecule (Nr-CAM) (Neuronal surface protein Bravo) (hBravo) (NgCAM-related cell adhesion molecule) (Ng-CAM-related)
Gene: NRCAM

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	12421765
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1481 Hs			1 1304
+	Rn
		88576 MAGI3_RAT (1-1480): 0: 822: 84.84		D3ZDA6_RAT (342-1298): 1.69e-88: 319: 17.84
+	Hs
		234530 MAGI3_HUMAN (1-1481): 0: 886: 100.00		DSCAM_HUMAN (3-961): 8.7e-59: 225: 11.77
+	Hs
		1136432 MAGI3_HUMAN (1-1481): 0: 886: 100.00		DSCL1_HUMAN (4-955): 7.84e-54: 209: 11.93
+	Mm
		1195001 DLG1_MOUSE (14-341): 2.85e-25: 115: 9.67		NRCAM_MOUSE (1-1304): 0: 839: 89.88
+	Mm
		1143386 DLG4_MOUSE (19-236): 3.76e-14: 79.6: 12.05		NRCAM_MOUSE (1-1304): 0: 839: 89.88
+	Hs
		234545 MAGI2_HUMAN (1-1356): 2.23e-159: 522: 40.55		DSCAM_HUMAN (3-961): 8.7e-59: 225: 11.77
+	Hs
		1199785 MAGI2_HUMAN (1-1356): 2.23e-159: 522: 40.55		DSCL1_HUMAN (4-955): 7.84e-54: 209: 11.93
+	Rn
		88569 D3ZWS0_RAT (14-720): 3.41e-39: 162: 12.94		D3ZDA6_RAT (342-1298): 1.69e-88: 319: 17.84
+	Rn
		88571 MAGI2_RAT (308-1386): 4.83e-35: 148: 12.55		D3ZDA6_RAT (342-1298): 1.69e-88: 319: 17.84
+	Rn
		88575 DLG2_RAT (2-207): 4.15e-26: 118: 14.22		D3ZDA6_RAT (342-1298): 1.69e-88: 319: 17.84
+	Rn
		88574 DLG3_RAT (16-398): 1.03e-23: 110: 8.70		D3ZDA6_RAT (342-1298): 1.69e-88: 319: 17.84
+	Mm
		524114 DLG4_MOUSE (19-236): 3.76e-14: 79.6: 12.05		CNTN1_MOUSE (267-1229): 1.41e-95: 332: 15.82
+	Rn
		88572 DLG4_RAT (13-291): 2.72e-14: 80: 9.96		D3ZDA6_RAT (342-1298): 1.69e-88: 319: 17.84
+	Hs
		234509 PTN13_HUMAN (83-1101): 5.15e-32: 139: 11.88		DSCAM_HUMAN (3-961): 8.7e-59: 225: 11.77
+	Hs
		234511 DLG1_HUMAN (14-594): 2.26e-26: 119: 9.03		DSCAM_HUMAN (3-961): 8.7e-59: 225: 11.77
+	Hs
		234522 DLG2_HUMAN (20-162): 2.63e-14: 80.4: 18.24		DSCAM_HUMAN (3-961): 8.7e-59: 225: 11.77
+	Hs
		234499 DLG4_HUMAN (13-291): 3.17e-14: 80: 9.96		DSCAM_HUMAN (3-961): 8.7e-59: 225: 11.77
+	Hs
		1123250 NHRF3_HUMAN (15-518): 1.23e-26: 118: 12.72		SDK2_HUMAN (736-1178): 2.94e-20: 100: 10.09
+	Mm
		936319 DLG4_MOUSE (19-236): 3.76e-14: 79.6: 12.05		DCC_MOUSE (3-781): 2.31e-31: 136: 13.01
+	Mm
		1143349 DLG4_MOUSE (19-236): 3.76e-14: 79.6: 12.05		SDK2_MOUSE (736-1178): 7.02e-20: 99.1: 9.87