HitPredict

Interactor 1: M9PAY7 (M9PAY7)
Pi3K21B, isoform C (Pi3K21B, isoform D)
Gene: Pi3K21B

Interactor 2: EGFR (P04412)
Epidermal growth factor receptor (Egfr) (EC 2.7.10.1) (Drosophila relative of ERBB) (Gurken receptor) (Protein torpedo)
Gene: EGFR

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.555

Property	Details
Experiments	17637670
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 197 Dm			1 1426
+	Hs
		433265 YES_HUMAN (2-192): 6.47e-60: 197: 17.91		EPHB2_HUMAN (518-1320): 5.69e-173: 547: 17.98
+	Mm
		403425 SRC_MOUSE (2-192): 6.89e-59: 194: 18.41		EPHB2_MOUSE (518-1257): 2.15e-174: 548: 18.81
+	Hs
		433359 YES_HUMAN (2-192): 6.47e-60: 197: 17.91		ERBB4_HUMAN (415-1408): 2.11e-156: 509: 25.96
+	Rn
		1225226 SRC_RAT (2-192): 4.55e-59: 194: 18.41		Q8K3F9_RAT (389-1407): 5.1e-137: 455: 25.54
+	Hs
		433229 YES_HUMAN (2-192): 6.47e-60: 197: 17.91		FGFR1_HUMAN (763-1251): 9.7e-130: 423: 23.88
+	Mm
		403421 SRC_MOUSE (2-192): 6.89e-59: 194: 18.41		RET_MOUSE (642-1289): 3.22e-125: 419: 19.44
+	Hs
		337329 SRC_HUMAN (2-192): 6.32e-59: 194: 18.41		ABL1_HUMAN (944-1194): 4.41e-51: 199: 42.52
+	Hs
		433329 YES_HUMAN (2-192): 6.47e-60: 197: 17.91		FAK1_HUMAN (934-1196): 1.82e-48: 191: 37.87
+	Rn
		693648 SRC_RAT (2-192): 4.55e-59: 194: 18.41		CSK_RAT (937-1190): 1.94e-52: 193: 40.47
+	Hs
		111147 YES_HUMAN (2-192): 6.47e-60: 197: 17.91		I6L996_HUMAN (934-1196): 2.2e-49: 189: 37.87
+	Mm
		403419 SRC_MOUSE (2-192): 6.89e-59: 194: 18.41		FAK1_MOUSE (934-1196): 1.36e-48: 191: 38.24
+	Mm
		403463 SRC_MOUSE (2-192): 6.89e-59: 194: 18.41		FAK2_MOUSE (943-1196): 1.54e-48: 191: 38.43
+	Mm
		403410 SRC_MOUSE (2-192): 6.89e-59: 194: 18.41		INSR_MOUSE (402-817): 5.76e-33: 141: 18.76
+	Hs
		433253 YES_HUMAN (2-192): 6.47e-60: 197: 17.91		ERBB3_HUMAN (85-429): 2.48e-31: 136: 19.85
+	Hs
		337789 YES_HUMAN (2-192): 6.47e-60: 197: 17.91		EGFR_HUMAN (100-413): 3.59e-29: 129: 19.49
+	Rn
		1351588 SRC_RAT (2-192): 4.55e-59: 194: 18.41		Q9QX70_RAT (100-425): 1.33e-29: 130: 20.17
+	Hs
		337850 SRC_HUMAN (2-192): 6.32e-59: 194: 18.41		EGFR_HUMAN (100-413): 3.59e-29: 129: 19.49
+	Mm
		403432 SRC_MOUSE (2-192): 6.89e-59: 194: 18.41		EGFR_MOUSE (100-412): 1.08e-27: 124: 20.18
+	Hs
		383538 YES_HUMAN (2-192): 6.47e-60: 197: 17.91		ERBB2_HUMAN (111-415): 5.1e-23: 109: 21.02
+	Hs
		383570 SRC_HUMAN (2-192): 6.32e-59: 194: 18.41		ERBB2_HUMAN (111-415): 5.1e-23: 109: 21.02