HitPredict

Interactor 1: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Interactor 2: PJA1 (Q8NG27)
E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1)
Gene: PJA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 321 Hs			1 643
+	Hs
		919792 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		PJA1_HUMAN (1-643): 1.23e-161: 480: 100.00
+	Hs
		196372 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		PJA2_HUMAN (1-642): 1.14e-129: 399: 44.94
+	Hs
		196294 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		PJA2_HUMAN (1-642): 1.14e-129: 399: 44.94
+	Hs
		1138930 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		RN150_HUMAN (523-643): 1.36e-29: 123: 23.39
+	Hs
		1138926 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		RN181_HUMAN (566-640): 6.22e-29: 114: 38.67
+	Hs
		865028 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		TTC3_HUMAN (29-635): 4.22e-87: 299: 12.34
+	Hs
		1346940 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RNF12_HUMAN (1-641): 4.33e-52: 191: 12.42
+	Hs
		919877 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RNF12_HUMAN (1-641): 4.33e-52: 191: 12.42
+	Hs
		1169203 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN111_HUMAN (33-643): 6.96e-48: 183: 13.06
+	Hs
		919758 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RN111_HUMAN (33-643): 6.96e-48: 183: 13.06
+	Zm
		74334 B4FC97_MAIZE (4-153): 6.2e-76: 231: 31.33		B6U926_MAIZE (392-640): 9.62e-39: 148: 21.83
+	Hs
		282607 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RNF8_HUMAN (383-639): 1.07e-34: 139: 16.85
+	Hs
		1377467 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN115_HUMAN (432-639): 6.28e-33: 130: 21.88
+	Hs
		1242076 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		ZNRF1_HUMAN (383-633): 8.23e-33: 128: 14.68
+	Hs
		919790 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		ZNRF1_HUMAN (383-633): 8.23e-33: 128: 14.68
+	Hs
		1356934 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN150_HUMAN (523-643): 1.36e-29: 123: 23.39
+	Hs
		1313520 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN126_HUMAN (545-639): 9.16e-30: 121: 40.00
+	Hs
		919840 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RN126_HUMAN (545-639): 9.16e-30: 121: 40.00
+	Hs
		1349753 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN181_HUMAN (566-640): 6.22e-29: 114: 38.67
+	Hs
		919885 UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67		RN181_HUMAN (566-640): 6.22e-29: 114: 38.67