HitPredict

Interactor 1: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Interactor 2: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0000209 - protein polyubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 321 Hs			1 232
+	Hs
		1138933 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		RN114_HUMAN (9-225): 2.79e-44: 150: 29.26
+	Hs
		1138899 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		RN166_HUMAN (1-224): 1.46e-42: 145: 30.83
+	Hs
		1138878 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI68_HUMAN (22-221): 5.24e-36: 134: 15.94
+	Hs
		1138921 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM2_HUMAN (17-227): 1.61e-34: 131: 13.97
+	Hs
		1138920 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM5_HUMAN (24-229): 2.94e-33: 126: 15.81
+	Hs
		536873 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		1138931 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI35_HUMAN (18-229): 2.74e-32: 124: 12.67
+	Hs
		1138916 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI34_HUMAN (31-167): 2.14e-26: 108: 20.14
+	Hs
		1138923 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		RNF41_HUMAN (37-120): 3.22e-10: 60.9: 24.18
+	Hs
		1290204 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN125_HUMAN (1-232): 1.03e-55: 179: 100.00
+	Hs
		1283434 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN166_HUMAN (1-224): 1.46e-42: 145: 30.83
+	Hs
		1336390 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI39_HUMAN (28-229): 3.66e-38: 140: 16.90
+	Hs
		1318532 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		1285831 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI43_HUMAN (24-229): 1.32e-35: 132: 15.09
+	Hs
		1318738 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRIM2_HUMAN (17-227): 1.61e-34: 131: 13.97
+	Hs
		1318719 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRIM5_HUMAN (24-229): 2.94e-33: 126: 15.81
+	Hs
		537142 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Hs
		1261313 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		RN138_HUMAN (21-222): 4.17e-34: 124: 26.25
+	Hs
		1357712 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI35_HUMAN (18-229): 2.74e-32: 124: 12.67
+	Hs
		1252560 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		LNX1_HUMAN (28-142): 7.17e-24: 101: 24.17